Photodegradation of trimeprazine triggered by self-photogenerated singlet molecular oxygen
Joint Authors
Zuhayr, Muhammad Rayhan
Gupta, Anamika
Iqbal, Jawaid
Ahmad, Wasim
Source
Journal of Saudi Chemical Society
Issue
Vol. 20, Issue 5 (30 Sep. 2016), pp.543-546, 4 p.
Publisher
Publication Date
2016-09-30
Country of Publication
Saudi Arabia
No. of Pages
4
Main Subjects
Abstract EN
The antihistaminic drug trimeprazine (1, also known as alimemazine) is photolabile under UV-A light in aerobic conditions.
Irradiation of a methanol solution of trimeprazine produces two photoproducts which were isolated as N,N2-trimethyl-3-(10H-phenothiazin-10-yl sulfoxide) propan-1-amine (2) and N,2-dimethyl-3-(10H-phenothiazin-10-yl) propan-1-amine (4).
The formation of products was explained by the oxidative photodegradation of trimeprazine in an irreversible trapping of the self-photogenerated 1O2 by the type II photodynamic action of the drug.
The generation of singlet oxygen during photolysis of trimeprazine was confirmed by singlet oxygen scavenger 2,5-dimethylfuran (2,5-DMF).
American Psychological Association (APA)
Ahmad, Wasim& Zuhayr, Muhammad Rayhan& Gupta, Anamika& Iqbal, Jawaid. 2016. Photodegradation of trimeprazine triggered by self-photogenerated singlet molecular oxygen. Journal of Saudi Chemical Society،Vol. 20, no. 5, pp.543-546.
https://search.emarefa.net/detail/BIM-706540
Modern Language Association (MLA)
Ahmad, Wasim…[et al.]. Photodegradation of trimeprazine triggered by self-photogenerated singlet molecular oxygen. Journal of Saudi Chemical Society Vol. 20, no. 5 (Sep. 2016), pp.543-546.
https://search.emarefa.net/detail/BIM-706540
American Medical Association (AMA)
Ahmad, Wasim& Zuhayr, Muhammad Rayhan& Gupta, Anamika& Iqbal, Jawaid. Photodegradation of trimeprazine triggered by self-photogenerated singlet molecular oxygen. Journal of Saudi Chemical Society. 2016. Vol. 20, no. 5, pp.543-546.
https://search.emarefa.net/detail/BIM-706540
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 545-546
Record ID
BIM-706540