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Synthesis, antimicrobial and antitubercular activities of some novel pyrazoline derivatives
Joint Authors
Abd al-Salam, Aftab Ahmad
Bhandari, Anil
Husayn, Asif
Mujib, Muhammad
Khan, Shah Alam
Source
Journal of Saudi Chemical Society
Issue
Vol. 20, Issue 5 (30 Sep. 2016), pp.577-584, 8 p.
Publisher
Publication Date
2016-09-30
Country of Publication
Saudi Arabia
No. of Pages
8
Main Subjects
Abstract EN
In the present study, two new series of pyrazolines (3a–h & 4a–h) were synthesized starting from p-acetamidophenol (paracetamol) and evaluated for their antibacterial, antifungal and antitubercular activities.
Chalcones (2a–h) prepared by condensing 3-acetyl-4-hydroxyphenyl acetamide (1) with different aromatic aldehydes were reacted with phenyl hydrazine and isonicotinic acid hydrazide to obtain phenyl-pyrazolines (3a–h) and isoniazid-pyrazolines (4a–h), respectively.
The structures of the synthesized compounds were confirmed by spectral and microanalysis studies.
Newly prepared pyrazoline compounds exhibited significant antibacterial activity against the organisms Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa when compared with the standard antibiotic Ciprofloxacin.
Compound 4g showed potent antibacterial activity against P.
aeruginosa and S.
aureus (MIC-3.12 lg/mL), however, against E.
coli compound 3d, 4c, 4d, 4f & 4g were found to have an MIC of 6.25 lg/mL.
Antifungal activity of compound 4d against Candida albicans and Aspergillus niger (MIC-3.12 lg/mL) was found to be better than the standard drug
American Psychological Association (APA)
Abd al-Salam, Aftab Ahmad& Husayn, Asif& Khan, Shah Alam& Bhandari, Anil& Mujib, Muhammad. 2016. Synthesis, antimicrobial and antitubercular activities of some novel pyrazoline derivatives. Journal of Saudi Chemical Society،Vol. 20, no. 5, pp.577-584.
https://search.emarefa.net/detail/BIM-706554
Modern Language Association (MLA)
Abd al-Salam, Aftab Ahmad…[et al.]. Synthesis, antimicrobial and antitubercular activities of some novel pyrazoline derivatives. Journal of Saudi Chemical Society Vol. 20, no. 5 (Sep. 2016), pp.577-584.
https://search.emarefa.net/detail/BIM-706554
American Medical Association (AMA)
Abd al-Salam, Aftab Ahmad& Husayn, Asif& Khan, Shah Alam& Bhandari, Anil& Mujib, Muhammad. Synthesis, antimicrobial and antitubercular activities of some novel pyrazoline derivatives. Journal of Saudi Chemical Society. 2016. Vol. 20, no. 5, pp.577-584.
https://search.emarefa.net/detail/BIM-706554
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 584
Record ID
BIM-706554