Anti-inflammatory and antimicrobial activities of novel pyrazole analogues
Joint Authors
Kumar, R. Surendra
Ahamid, Anis
Idhayadhulla, Akbar
Arif, Ibrahim Abd al-Wahid
Source
Saudi Journal of Biological Sciences
Issue
Vol. 23, Issue 5 (30 Sep. 2016), pp.614-620, 7 p.
Publisher
Publication Date
2016-09-30
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Abstract EN
A new sequence of pyrazole derivatives (1–6) was synthesized from condensation technique under utilizing ultrasound irradiation.
Synthesized compounds were characterized from IR, 1H NMR, 13C NMR, Mass and elemental analysis.
Synthesized compounds (1–6) were screened for antimicrobial activity.
Among the compounds 3 (MIC: 0.25 lg/mL) was exceedingly antibacterially active against gram negative bacteria of Escherichia coli and compound 4 (MIC: 0.25 lg/mL) was highly active against gram positive bacteria of Streptococcus epidermidis compared with standard Ciprofloxacin.
Compound 2 (MIC: 1 lg/mL) was highly antifungal active against Aspergillus niger proportionate to Clotrimazole.
Synthesized compounds (1–6) were screened for antiinflammatory activity and the compound 2-((5-hydroxy-3-methyl-1H-pyrazol-4-yl)(4-nitrophenyl) methyl)hydrazinecarboxamide (4) was better activity against anti-inflammatory when compared with standard drugs (Diclofenac sodium).
Compounds (2, 3 and 4) are the most important molecules and hence the need to develop new drugs of antibacterial, antifungal and anti-inflammatory agents.
ھ 2015 The Authors.
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This is an open access article under theCCBY-NC-NDlicense (http://creativecommons.org/licenses/by-nc-nd/4.0/).
American Psychological Association (APA)
Kumar, R. Surendra& Arif, Ibrahim Abd al-Wahid& Ahamid, Anis& Idhayadhulla, Akbar. 2016. Anti-inflammatory and antimicrobial activities of novel pyrazole analogues. Saudi Journal of Biological Sciences،Vol. 23, no. 5, pp.614-620.
https://search.emarefa.net/detail/BIM-707945
Modern Language Association (MLA)
Kumar, R. Surendra…[et al.]. Anti-inflammatory and antimicrobial activities of novel pyrazole analogues. Saudi Journal of Biological Sciences Vol. 23, no. 5 (Sep. 2016), pp.614-620.
https://search.emarefa.net/detail/BIM-707945
American Medical Association (AMA)
Kumar, R. Surendra& Arif, Ibrahim Abd al-Wahid& Ahamid, Anis& Idhayadhulla, Akbar. Anti-inflammatory and antimicrobial activities of novel pyrazole analogues. Saudi Journal of Biological Sciences. 2016. Vol. 23, no. 5, pp.614-620.
https://search.emarefa.net/detail/BIM-707945
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 620
Record ID
BIM-707945