![](/images/graphics-bg.png)
Synthesis of hetero cyclic compounds pyrazole and pyridiazine from 3-methylbutane hydrazide derivatives with evaluating of its biological activity
Author
Source
Iraqi National Journal of Chemistry
Issue
Vol. 15, Issue 4 (31 Dec. 2015), pp.294-306, 13 p.
Publisher
University of Babylon College of Sciences
Publication Date
2015-12-31
Country of Publication
Iraq
No. of Pages
13
Main Subjects
Abstract EN
Condensation of (S)-2-(N-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)pentanamido)-3-methylbutanoic acid with methanol in acetic acid give methyl (S)-methyl 2-(N-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)pentanamido)-3-methylbutanoate compound (1).Reaction of compound(1) with hydrazine hydrate resulted 3-methyl butane hydrazide derivatives (2).
Treatmentof(2) with malic anhydride, phthalic anhydride ,succinic anhydride afford pyridiazine derivatives (3-5)and then with acetylacetone, ethylacetoacetate, afford a new derivatives pyrazole compound (6-8) and evaluation of biological activity for some of them.
The identification of isolated and purified compounds are elucidated by 1HNMR, IR.
American Psychological Association (APA)
Lihimis, Halah Shakir. 2015. Synthesis of hetero cyclic compounds pyrazole and pyridiazine from 3-methylbutane hydrazide derivatives with evaluating of its biological activity. Iraqi National Journal of Chemistry،Vol. 15, no. 4, pp.294-306.
https://search.emarefa.net/detail/BIM-708446
Modern Language Association (MLA)
Lihimis, Halah Shakir. Synthesis of hetero cyclic compounds pyrazole and pyridiazine from 3-methylbutane hydrazide derivatives with evaluating of its biological activity. Iraqi National Journal of Chemistry Vol. 15, no. 4 (2015), pp.294-306.
https://search.emarefa.net/detail/BIM-708446
American Medical Association (AMA)
Lihimis, Halah Shakir. Synthesis of hetero cyclic compounds pyrazole and pyridiazine from 3-methylbutane hydrazide derivatives with evaluating of its biological activity. Iraqi National Journal of Chemistry. 2015. Vol. 15, no. 4, pp.294-306.
https://search.emarefa.net/detail/BIM-708446
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 304-306
Record ID
BIM-708446