Gemcitabine-oxaliplatin (GEMOX) for epithelial ovarian cancer patients resistant to platinum-based chemotherapy
Joint Authors
al-Shirbini, Muhammad
al-Mursi, Walid
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 28, Issue 3 (30 Sep. 2016), pp.183-189, 7 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2016-09-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background : Patients with platinum-resistant epithelial ovarian cancer (EOC) experience poor outcome.
Currently, no clearly superior management strategy exists for platinumresistant EOC patients.
Purpose : Analyze the efficacy and safety of gemcitabine–oxaliplatin (GEMOX) in platinum resistant EOC patients.
Patients and methods : Thirty-two patients with platinum-based resistant EOC were included.
Studied patients had received GEM at the dose of 1000 mg/m2 on days 1 and 8 and OX 100 mg/m2 on day 1, administered over 2 h 30 min after GEM infusion of 3 week treatment cycle.
Results: In the evaluation of tumor response, none of patients had achieved CR while PR, SD, were observed in 7 (21.9 %), 9 (28.1%) respectively, clinical benefit (CR+ PR +SD) was recorded in 50 % of patients while PD was observed in 16 (50 %) patients.
In regard to survival, the median value of OS was 10.5 months (range, 2.2–17.5 months).
The median value of PFS was 6.37 months (range, 1–17.5 months).
The one-year OS rate was 34.4% and the one-year PFS rate was 12.5 %.
Concerning hematological toxicity grade 3 neutropenia was recorded in 4 (12.5 %) patients while grade 4 febrile neutropenia was recorded in 2 (6.3 %) patients and grade 4 anemia was represented by 3.1%.
Grade 1–2 fatigue was the most common non-hematological toxicity and represented by 65.6 % of patients.
Grade 3 non hematological toxicity was recorded with nausea/vomiting and hepatic toxicity represented by 3.1 % for both.
American Psychological Association (APA)
al-Shirbini, Muhammad& al-Mursi, Walid. 2016. Gemcitabine-oxaliplatin (GEMOX) for epithelial ovarian cancer patients resistant to platinum-based chemotherapy. Journal of the Egyptian National Cancer Institute،Vol. 28, no. 3, pp.183-189.
https://search.emarefa.net/detail/BIM-708746
Modern Language Association (MLA)
al-Shirbini, Muhammad& al-Mursi, Walid. Gemcitabine-oxaliplatin (GEMOX) for epithelial ovarian cancer patients resistant to platinum-based chemotherapy. Journal of the Egyptian National Cancer Institute Vol. 28, no. 3 (Sep. 2016), pp.183-189.
https://search.emarefa.net/detail/BIM-708746
American Medical Association (AMA)
al-Shirbini, Muhammad& al-Mursi, Walid. Gemcitabine-oxaliplatin (GEMOX) for epithelial ovarian cancer patients resistant to platinum-based chemotherapy. Journal of the Egyptian National Cancer Institute. 2016. Vol. 28, no. 3, pp.183-189.
https://search.emarefa.net/detail/BIM-708746
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 188-189
Record ID
BIM-708746