Synthesis and preliminary evaluation of the antibacterial activity of some new compounds from nucleophilic acyl substitution and ring opening reactions of 5(4h)‎-oxazolones

Abstract EN

substituted dehydroamino acid derivatives were efficaciously synthesized from the nucleophilic acyl substitution and ring opening reaction of 4-arylidene-2-phenyl-5(4H)-oxazolones (1) using an appropriate synthetic strategy.

All synthesized compounds were screened for their in vitro antibacterial activities against two identifiable strains using cup plate method.

Thereby, it was found that the benzocaine and ester derivatives of N-substituted dehydroamino acids (3 and 6-9) revealed promising antibacterial activity against both strains, while none of the synthesized 1, 3-imidazolones (2) exhibited likely result against Escherichia coli and Staphylococcus aureus.

Supplementary to these, the constitutions of the newly synthesized 1, 3-imidazolones and N-substituted dehydroamino acid derivatives have been confirmed on the basis of their IR, 1H- and 13C-NMR spectral data.