الموجودات المناعية النسيجية و التشريحية المرضية الجزيئية المحددة لحالة الجين الوَرَمِيّ HER2-neuc-erbB-2 في سرطان الثدي الغازي

Abstract EN

The research aimed to confirm the importance of the immunohistochemestry with chromogenic in situ hybridization (CISH) to determine the HER2-neu (c-erbB-2) in invasive breast cancers.

Use a new technique in molecular pathology by CISH، in addition to reveal the findings that are determined the HER2-neu status by used immunohistochemistry and molecular pathology.

A random study of 50 cases of invasive breast cancer, which obtained from the laboratory of al-Birouni hospital (2010).

These cases were studied in the pathology department, Faculty of medicine, Damascus university, by the Chromogenic in-situ Hybridization (FISH duo CISH) and Immunohistochemistry (IHC).

And by comparison with other international studies, we conclude that the result of IHC is important for the orientation to determine HER2 status, but the final result is by CISH together with IHC.

It is very important to consider the CISH technique as a routine examination for all invasive breast cancer patients along with the immunohistochemistry, especially in borderline cases