دراسة التلوث الجرثومي و الفطري لبعض الأشكال الصيدلانية الفموية المائية المصنعة محليا

Abstract EN

The study aims to evaluate the efficacy of preservatives of different non-sterile Syrian aqueous oral syrups.

The clinical isolates microorganisms were characterized according to their biochemical properties by using standard method to their identification.

The identified microorganisms were inoculated into tested syrups with 105-107 cfu/ml which were then incubated for 14 days.

Growth of microorganisms into syrup was compared by counting the CFUs from a subculture of inoculated syrup at different time (0, 3, 6, 12, 24 hrs, 3, 7, 14 and 28 days).

The data exhibited great reduction of the CFUs count of each used microorganisms in all tested syrups after one week of incubation time , the count of CFUs was zero with all syrup, except anti-acid suspension which the count of CFUs maintained around 102 after 14 days of incubation time with all used microorganisms.

The results revealed that the Antimicrobial effectiveness of preservation systems of all examined syrups were excellent according to the USP scales.