Immunohistochemical expressions of AKT, ATM and cyclin E in oral squamous cell carcinoma
Joint Authors
Sarkis, Seta A.
Khalil, Afrah A.
Source
Journal of Baghdad College of Dentistry
Issue
Vol. 28, Issue 3 (30 Sep. 2016), pp.44-51, 8 p.
Publisher
University of Baghdad College of Dentistry
Publication Date
2016-09-30
Country of Publication
Iraq
No. of Pages
8
Main Subjects
Abstract EN
Background : Understanding the pathogenesis and molecular basis of Oral Squamous Cell Carcinoma (OSCC) has increased rapidly over the past few years that is essential to improve patient's prognosis and treatment modalities.
The purpose of this study to evaluate the Immunohistochemical expressions of AKT, ATM, AND Cyclin E in oral squamous cell carcinoma Materials and methods : This study was performed on a forty formalin-fixed paraffin-embedded blocks which histopathologically diagnosed as Oral Squamous Cell Carcinoma.
All cases were collected from the Histopathological Laboratory from patients treated surgically at Maxillofacial surgery Department at Ramadi Teaching Hospital, Iraq.
Results : The immunohistochemical staining of AKT showed positive expression in 38 (95 %), ATM showed positive expression in 38(95 %) and Cyclin E showed positive expression in 36(90 %) of the cases.
Conclusion : A statically significant correlation was found regarding the immunohistochemical expression of AKT with tumor grade and stage, Cyclin E with the age group and ATM with the clinical appearance.
American Psychological Association (APA)
Khalil, Afrah A.& Sarkis, Seta A.. 2016. Immunohistochemical expressions of AKT, ATM and cyclin E in oral squamous cell carcinoma. Journal of Baghdad College of Dentistry،Vol. 28, no. 3, pp.44-51.
https://search.emarefa.net/detail/BIM-709316
Modern Language Association (MLA)
Khalil, Afrah A.& Sarkis, Seta A.. Immunohistochemical expressions of AKT, ATM and cyclin E in oral squamous cell carcinoma. Journal of Baghdad College of Dentistry Vol. 28, no. 3 (Sep. 2016), pp.44-51.
https://search.emarefa.net/detail/BIM-709316
American Medical Association (AMA)
Khalil, Afrah A.& Sarkis, Seta A.. Immunohistochemical expressions of AKT, ATM and cyclin E in oral squamous cell carcinoma. Journal of Baghdad College of Dentistry. 2016. Vol. 28, no. 3, pp.44-51.
https://search.emarefa.net/detail/BIM-709316
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 50-51
Record ID
BIM-709316