β-catenin expression and its relation to bryne’s invasive grading system in oral squamous cell carcinoma
Joint Authors
Muhammad, Dina Nazim
Hamid, Marwah Abd al-Salam
Gharib, Balqis Taha
Source
Journal of Baghdad College of Dentistry
Issue
Vol. 28, Issue 3 (30 Sep. 2016), pp.52-58, 7 p.
Publisher
University of Baghdad College of Dentistry
Publication Date
2016-09-30
Country of Publication
Iraq
No. of Pages
7
Main Subjects
Abstract EN
Background : Invasion in oral cancer involves alterations in cell-cell and cell-matrix interactions that accompanied by loss of cell adhesion.
Catenins stabilize cellular adherence junctions by binding to E-cadherin, which further mediates cell-cell adhesion and regulates proliferation and differentiation of epithelial cells.
The Wnt/β-catenin pathway is one of the major signaling pathways in cell proliferation, oncogenesis, and epithelial-mesenchymal transition.
Aims of the study : to detect immunohistochemical distribution pattern and different subcellular localization of β-catenin in oral squamous cell carcinoma and relate such expression to Bryne’s invasive grading system.
Materials and Methods : This study included 30 paraffin blocks of primary oral squamous cell carcinoma.
Bryne’s grading performed on routein stained slides.
Immunohistochemical staining for anti β-catenin was done to illustrate its pattern and subcellular localization in malignant cells.
The expression correlated with the invasive grading system.
Results : β-catenin expression detected in all sample (100 %).
It was (23.3 %) membranous, (60 %) aberrant cytoplasmic and (16.7 %) mixed expression.
Diffuse strong homogeneous pattern was observed in (40%) of the cases.
The cytoplasmic expression had significant high mean rank in score 3, diffuse strong homogeneous pattern and strong intensity.
Well-differentiated carcinoma expressed great mixed membranous/cytoplasmic expression while poordifferentiated cases showed low membranous mean rank expression.
The strong diffuse homogeneous pattern with strong staining was significantly frequent in well-differentiated squamous cell carcinoma.
Conclusion : Increase cytoplasmic β-catenin expression is parallel with carcinoma dedifferentiation.
Suggesting maintenance of its adhesive role with the inhibition of the normal degradation of free β-catenin in the cytoplasm, which might cause accelerated tumor cell proliferation
American Psychological Association (APA)
Hamid, Marwah Abd al-Salam& Gharib, Balqis Taha& Muhammad, Dina Nazim. 2016. β-catenin expression and its relation to bryne’s invasive grading system in oral squamous cell carcinoma. Journal of Baghdad College of Dentistry،Vol. 28, no. 3, pp.52-58.
https://search.emarefa.net/detail/BIM-709319
Modern Language Association (MLA)
Hamid, Marwah Abd al-Salam…[et al.]. β-catenin expression and its relation to bryne’s invasive grading system in oral squamous cell carcinoma. Journal of Baghdad College of Dentistry Vol. 28, no. 3 (Sep. 2016), pp.52-58.
https://search.emarefa.net/detail/BIM-709319
American Medical Association (AMA)
Hamid, Marwah Abd al-Salam& Gharib, Balqis Taha& Muhammad, Dina Nazim. β-catenin expression and its relation to bryne’s invasive grading system in oral squamous cell carcinoma. Journal of Baghdad College of Dentistry. 2016. Vol. 28, no. 3, pp.52-58.
https://search.emarefa.net/detail/BIM-709319
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 57-58
Record ID
BIM-709319