Immunohistochemical expression of MMP2, VEGF and d2-40 as biological markers of local invasion potential, angiogenesis and lymphangiogenesis in oral squamous cell carcinoma and verrucous carcinoma
Joint Authors
Baqir, Ruqayah G.
Abd Allah, Bashshar H.
Source
Journal of Baghdad College of Dentistry
Issue
Vol. 28, Issue 3 (30 Sep. 2016), pp.59-64, 6 p.
Publisher
University of Baghdad College of Dentistry
Publication Date
2016-09-30
Country of Publication
Iraq
No. of Pages
6
Main Subjects
Abstract EN
Background : Verrucous carcinoma (VSCC) is considered as a rare well differentiated carcinoma variant of SCC with no metastatic potential.
The aim of this study is to evaluate the Immunohistochemical expression MMP-2, VEGF and D2-40 expression in OSCC and VSCC.
Materials and methods : Thirty formalin fixed paraffin embedded tissue blocks of OSCC and another twelve VSCC were collected and Four micrometer thick sections were cut from each block and mounted on positively charged slides and stained immunohistochemically with monoclonal antibodies to MMP-2, VEGF and D2-40.
Results : there is no statistical difference between SCC and VSCC regarding the immunoexpression of MMP-2 and VEGF.
While the lymphatic vessels density were higher in SCC than VSCC Conclusions : OSCC and VSCC bear similar local invasion and angiogenesis potentials when quantified with MMP-2 and VEGF immunostaining respectively whereas OSCC have higher lymphatic vessels density than their VSCC as evaluated with D2-40 immunoexpression
American Psychological Association (APA)
Baqir, Ruqayah G.& Abd Allah, Bashshar H.. 2016. Immunohistochemical expression of MMP2, VEGF and d2-40 as biological markers of local invasion potential, angiogenesis and lymphangiogenesis in oral squamous cell carcinoma and verrucous carcinoma. Journal of Baghdad College of Dentistry،Vol. 28, no. 3, pp.59-64.
https://search.emarefa.net/detail/BIM-709322
Modern Language Association (MLA)
Baqir, Ruqayah G.& Abd Allah, Bashshar H.. Immunohistochemical expression of MMP2, VEGF and d2-40 as biological markers of local invasion potential, angiogenesis and lymphangiogenesis in oral squamous cell carcinoma and verrucous carcinoma. Journal of Baghdad College of Dentistry Vol. 28, no. 3 (Sep. 2016), pp.59-64.
https://search.emarefa.net/detail/BIM-709322
American Medical Association (AMA)
Baqir, Ruqayah G.& Abd Allah, Bashshar H.. Immunohistochemical expression of MMP2, VEGF and d2-40 as biological markers of local invasion potential, angiogenesis and lymphangiogenesis in oral squamous cell carcinoma and verrucous carcinoma. Journal of Baghdad College of Dentistry. 2016. Vol. 28, no. 3, pp.59-64.
https://search.emarefa.net/detail/BIM-709322
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 63-64
Record ID
BIM-709322