Association of hla class ii alleles (DRB1 and DQB1) in Iraqi Women with endometriosis
Joint Authors
al-Tai, Muhammad Ibrahim Nadir Mahmud
Ali, Aminah M.
Ahmad K. Muhammad
al-Ghurabi, Batul H.
Source
Iraqi Journal of Biotechnology
Issue
Vol. 15, Issue 2 (31 Dec. 2016), pp.42-50, 9 p.
Publisher
University of Baghdad Genetic Engineering and Biotechnology for Postgraduate Studies
Publication Date
2016-12-31
Country of Publication
Iraq
No. of Pages
9
Main Subjects
Topics
Abstract EN
Endometriosis is a chronic gynecological disease manifested by the occurrence of ectopic foci of endometrial tissue in the pelvic cavity and/or ovary.
Etiopathogenesis of the disease is still poorly understood but there is a growing bulk of evidence that genetic factors and immunological abnormalities play a role in this disease.
This study was performed to investigate the association of human leukocyte antigens class II genotypes (HLA-DR and DQ) with the susceptibility to endometriosis.
Fifty female patients with endometriosis their age range (19 – 46) years and 30 females as control their ages were matched with the patients were enrolled in this study.
Blood was collected from patients and controls, DNA was extracted from blood samples, and then HLA- genotyping was performed by polymerase chain reaction-sequence specific oligonucleotide probes (PCR-SSO).
The present findings showed that DRB1*0307, DRB1*0701 and DQB1*0301 alleles were found with highly significant frequencies among patients (22 %; 34% and 24 %), in comparison with healthy control (0.0%) for three alleles, (P <0.001).
On the other hand, it was observed that HLA-DRB1*0323 in high frequency among healthy individuals (23.3%) rather than in the patients (0.0%); with (P <0.001).
This study demonstrates that HLA- DRB1*0307, DRB1*0701 and DQB1*0301 alleles may contribute to the increased susceptibility to endometriosis, whereas HLA-DRB1*0323 allele may confer protective effects against it, suggesting HLA-based different etiopathogenesis.
American Psychological Association (APA)
Ali, Aminah M.& al-Tai, Muhammad Ibrahim Nadir Mahmud& al-Ghurabi, Batul H.& Ahmad K. Muhammad. 2016. Association of hla class ii alleles (DRB1 and DQB1) in Iraqi Women with endometriosis. Iraqi Journal of Biotechnology،Vol. 15, no. 2, pp.42-50.
https://search.emarefa.net/detail/BIM-709468
Modern Language Association (MLA)
Ali, Aminah M.…[et al.]. Association of hla class ii alleles (DRB1 and DQB1) in Iraqi Women with endometriosis. Iraqi Journal of Biotechnology Vol. 15, no. 2 (2016), pp.42-50.
https://search.emarefa.net/detail/BIM-709468
American Medical Association (AMA)
Ali, Aminah M.& al-Tai, Muhammad Ibrahim Nadir Mahmud& al-Ghurabi, Batul H.& Ahmad K. Muhammad. Association of hla class ii alleles (DRB1 and DQB1) in Iraqi Women with endometriosis. Iraqi Journal of Biotechnology. 2016. Vol. 15, no. 2, pp.42-50.
https://search.emarefa.net/detail/BIM-709468
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 49-50
Record ID
BIM-709468