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Dexmedetomidine versus fentanyl as adjuvant to epidural 0.5% levobupivacaine for transurethral prostate resection in elderly patients : a comparative evaluation
Joint Authors
Sharma, Deepak
Guptaa, Kumkum
Guptab, Prashant K.
Rastogia, Bhawana
Jaina, Manish
Pandey, Mahesh Narayan
Source
Ain Shams Journal of Anesthesiology
Issue
Vol. 9, Issue 3 (30 Sep. 2016), pp.398-402, 5 p.
Publisher
Ain Shams University Faculty of Medicine Department of Anesthesiology
Publication Date
2016-09-30
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Regional anesthesia is the technique of choice for patients undergoing transurethral resection of the prostate (TURP), but anesthetic management of elderly patients is challenging due to compromised organ function.
The present study aimed to evaluate the relative efficacy and safety of dexmedetomidine versus fentanyl in the enhancement of the quality and duration of epidural anesthesia with 0.5% levobupivacaine and hemodynamic stability during TURP in elderly patients.
Patients and methods Sixty elderly consented patients were randomized into two equal groups of 30 patients each in a double-blind manner.
They were given 15 ml of 0.5% levobupivacaine (75 mg) either with 1 ml (50 μg) dexmedetomidine (group LD) or with 1 ml (50 μg) fentanyl (group LF) using an epidural catheter.
The primary endpoints were the onset and duration of sensory and motor blockade, duration of sensory analgesia, hemodynamic variability, respiratory adequacy, and any adverse effect.
Results Demographic data were comparable in both groups.
Onset of sensory and motor blockade was faster in patients of group LD than in patients of group LF, with a statistically significant difference (P < 0.05).
Duration of motor blockade and sensory analgesia was longer in patients of group LD than in patients of group LF (P < 0.05).
Intraoperative heart rate and mean arterial blood pressure were significantly lower in patients of group LD, but no intervention was required.
Surgical bleeding was reduced in patients of group LD.
Conclusion Dexmedetomidine as an adjuvant to epidural levobupivacaine for TURP has shortened onset time of anesthesia and prolonged duration of sensory analgesia.
The surgical field vision was improved due to reduced bleeding
American Psychological Association (APA)
Guptaa, Kumkum& Guptab, Prashant K.& Rastogia, Bhawana& Jaina, Manish& Sharma, Deepak& Pandey, Mahesh Narayan. 2016. Dexmedetomidine versus fentanyl as adjuvant to epidural 0.5% levobupivacaine for transurethral prostate resection in elderly patients : a comparative evaluation. Ain Shams Journal of Anesthesiology،Vol. 9, no. 3, pp.398-402.
https://search.emarefa.net/detail/BIM-709984
Modern Language Association (MLA)
Guptaa, Kumkum…[et al.]. Dexmedetomidine versus fentanyl as adjuvant to epidural 0.5% levobupivacaine for transurethral prostate resection in elderly patients : a comparative evaluation. Ain Shams Journal of Anesthesiology Vol. 9, no. 3 (Jul. / Sep. 2016), pp.398-402.
https://search.emarefa.net/detail/BIM-709984
American Medical Association (AMA)
Guptaa, Kumkum& Guptab, Prashant K.& Rastogia, Bhawana& Jaina, Manish& Sharma, Deepak& Pandey, Mahesh Narayan. Dexmedetomidine versus fentanyl as adjuvant to epidural 0.5% levobupivacaine for transurethral prostate resection in elderly patients : a comparative evaluation. Ain Shams Journal of Anesthesiology. 2016. Vol. 9, no. 3, pp.398-402.
https://search.emarefa.net/detail/BIM-709984
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 422
Record ID
BIM-709984