دراسة الاستجابة المناعية ضد بعض المستضدات الرئيسة لليشمانية
Other Title(s)
Study for the immune response against some major antigens of leishmania
Joint Authors
قويدر، محمود
العقلة، سعاد
السلوم، نتالي
معروف، محمد
Source
Issue
Vol. 6, Issue 2 (31 Jul. 2011)6 p.
Publisher
Syrian Clinical Laboratory Association
Publication Date
2011-07-31
Country of Publication
Syria
No. of Pages
6
Main Subjects
Abstract EN
Leishmaniasis is condidered to be dispersed in Syria, and because of the side effects that caused by drugs and resistant to them, so the prevention is very important to stop dispersing the disease.
For that, our study aimed to evaluate the role of cellular immune response (IFN-γ) and humoral immune response (IgG) that induced by the total extract of L.
tropica or the mixed of 63 and 43 KDa antigens which are taken from the same strain.
In this study we used fifteen BALB/c mice divided into three groups.
The first was immunized by total extract of L.
tropica with incomplete frond adjuvant (IFA), and the second group was immunized with the mixed of two proteins.
43, 63 KDa with IFA, and the control group was inoculated with phosphate saline buffer (PBS).
we observed that each total extract and mixed proteins induce Th1 response and possible Th2 response, but this response was significantly stronger with the mixed proteins p=3.6x10-5 for IFN-γ titer and p=4.8x10-6 for IgG titer which is considered a positive signal to continue studying to reach to an effective and safe vaccine
American Psychological Association (APA)
السلوم، نتالي والعقلة، سعاد وقويدر، محمود ومعروف، محمد. 2011. دراسة الاستجابة المناعية ضد بعض المستضدات الرئيسة لليشمانية. مجلة التشخيص المخبري،مج. 6، ع. 2.
https://search.emarefa.net/detail/BIM-710105
Modern Language Association (MLA)
معروف، محمد....[و آخرون]. دراسة الاستجابة المناعية ضد بعض المستضدات الرئيسة لليشمانية. مجلة التشخيص المخبري مج. 6، ع. 2 (تموز 2011).
https://search.emarefa.net/detail/BIM-710105
American Medical Association (AMA)
السلوم، نتالي والعقلة، سعاد وقويدر، محمود ومعروف، محمد. دراسة الاستجابة المناعية ضد بعض المستضدات الرئيسة لليشمانية. مجلة التشخيص المخبري. 2011. مج. 6، ع. 2.
https://search.emarefa.net/detail/BIM-710105
Data Type
Journal Articles
Language
Arabic
Notes
يتضمن مراجع ببليوجرافية
Record ID
BIM-710105