مقايسة الأضداد الذاتية للبروتين الكابت للورم p53 لدى مرضى سرطان القولون و المستقيم
Other Title(s)
Tumor suppressor protein p53 autoantibodies assay in colorectal cancer patients
Joint Authors
الصالح، جمانة
ملص، أنس
عطايا، عبدو
Source
Issue
Vol. 5, Issue 9 (31 Oct. 2010)6 p.
Publisher
Syrian Clinical Laboratory Association
Publication Date
2010-10-31
Country of Publication
Syria
No. of Pages
6
Main Subjects
Abstract EN
Background: Mutation of the p53 tumer suppressor gene is the most common genetic alteration in colorectal cancer, and detection of p53 antibodies in serum might be an effective indirect procedure to detect alterations of the p53 gene.
Aim: This study aimed to detect the presence of p53 antibodies in patient with colorectal cancer, and to study the association between this antibodies and tumor stage, tumor location, gender, age and smoking.
Method: we analyzed serum for p53 antibody using Enzyme linked Immune-adsorbent assay in 57 patients of colorectal cancer and 33 patients of benign disease in gastrointestinal (Crohn's Disease,Ulcerative Colitis) and 35 healthy individuals.
Results: Eight of seventy five colorectal cancer patients were positive for p53 antibodies (14%), and p53 antibodies weren’t detected in patients with benign gastrointestinal diseases, neither in healthy subjects (control group).
The difference was statistically significant (p<0.05).
We found no significant association between the frequency of anti-p53 antibodies and tumor size, tumor location, gender and smoking.
However sero-positive patients were older than sero-negative patients.
Conclusion: p53 antibodies are a specific tumer marker of colorectal cancer, and there is no association between the frequency of anti-p53 antibodies and tumor size, tumer location, gender and smoking
American Psychological Association (APA)
ملص، أنس وعطايا، عبدو والصالح، جمانة. 2010. مقايسة الأضداد الذاتية للبروتين الكابت للورم p53 لدى مرضى سرطان القولون و المستقيم. مجلة التشخيص المخبري،مج. 5، ع. 9.
https://search.emarefa.net/detail/BIM-710127
Modern Language Association (MLA)
ملص، أنس....[و آخرون]. مقايسة الأضداد الذاتية للبروتين الكابت للورم p53 لدى مرضى سرطان القولون و المستقيم. مجلة التشخيص المخبري مج. 5، ع. 9 (تشرين الأول 2010).
https://search.emarefa.net/detail/BIM-710127
American Medical Association (AMA)
ملص، أنس وعطايا، عبدو والصالح، جمانة. مقايسة الأضداد الذاتية للبروتين الكابت للورم p53 لدى مرضى سرطان القولون و المستقيم. مجلة التشخيص المخبري. 2010. مج. 5، ع. 9.
https://search.emarefa.net/detail/BIM-710127
Data Type
Journal Articles
Language
Arabic
Notes
يتضمن مراجع ببليوجرافية
Record ID
BIM-710127