استخدام التبئير الكهرساوي و التلطيخ المناعي لتشخيص التصلب المتعدد

Other Title(s)

Using of isoelectric focusing and immunoblotting for the diagnosis of multiple sclerosis

Joint Authors

القبيلي، فايزة
أبو خميس، عماد الدين
بحبوح، ميس

Source

مجلة التشخيص المخبري

Issue

Vol. 5, Issue 10 (31 Jan. 2011)8 p.

Publisher

Syrian Clinical Laboratory Association

Publication Date

2011-01-31

Country of Publication

Syria

No. of Pages

8

Main Subjects

Medicine

Abstract EN

Multiple Sclerosis (MS) is one of the major autoimmune and demyelination diseases of the central nervous system (CNS).

This shows a particular pattern of antibodies, it is Oligoclonal IgG in cerebrospinal fluid of multiple sclerosis patients, it shows an inflammatory activity of the lymphocytes within the CNS.

The presence of these antibodies can be investigated using Isoelectric Focusing method, followed by Immunoblotting, where Oligoclonal Bands appear in the CSF and not in the serum of the patient of MS in all stages of the disease.

Our study aimed to examine the sensitivity and specificity of Oligoclonal Bands IgG test in patients with multiple sclerosis, compared with patients with other neurological diseases (OND), and compare this method with the common diagnostic methods such as evoked potential and IgG Index test.

This study included two groups of patients: The first group consisted of 50 MS patients (28 females and 22 males).

While the second group consisted of 25 patients with OND diseases (15 females and 10 males).

The results showed that age, gender, and age of onset has no influence on the the disease, while the type of the disease, specially Relapsing Remitting "RR" type, has the susceptible affect on it.

The sensitivity of the method was to a level of 90% while, the specificity of was at 92%

American Psychological Association (APA)

بحبوح، ميس والقبيلي، فايزة وأبو خميس، عماد الدين. 2011. استخدام التبئير الكهرساوي و التلطيخ المناعي لتشخيص التصلب المتعدد. مجلة التشخيص المخبري،مج. 5، ع. 10.
https://search.emarefa.net/detail/BIM-710139

Modern Language Association (MLA)

بحبوح، ميس....[و آخرون]. استخدام التبئير الكهرساوي و التلطيخ المناعي لتشخيص التصلب المتعدد. مجلة التشخيص المخبري مج. 5، ع. 10 (كانون الثاني 2011).
https://search.emarefa.net/detail/BIM-710139

American Medical Association (AMA)

بحبوح، ميس والقبيلي، فايزة وأبو خميس، عماد الدين. استخدام التبئير الكهرساوي و التلطيخ المناعي لتشخيص التصلب المتعدد. مجلة التشخيص المخبري. 2011. مج. 5، ع. 10.
https://search.emarefa.net/detail/BIM-710139

Data Type

Journal Articles

Language

Arabic

Notes

يتضمن مراجع ببليوجرافية : ص. 7-8

Record ID

BIM-710139