Cyclosporine therapy in steroid-dependent or steroid-resistant idiopathic focal and segmental glomerulosclerosis
Joint Authors
Gorsane, Imen
Hilal, I.
Yaqub, I.
Ibn Abd Allah, T.
Abd al-Rahim, E.
Bin Hamidah, F.
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 27, Issue 5 (31 Oct. 2016), pp.958-965, 8 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2016-10-31
Country of Publication
Saudi Arabia
No. of Pages
8
Main Subjects
Topics
Abstract EN
Focal and segmental glomerulosclerosis (FSGS) is a heterogeneous entity.
Previous few studies have evaluated the efficacy of calcineurin inhibitors in primary FSGS and have suggested positive benefit.
In this single-center, retrospective study (1975–2014), we report our experience in Tunisian adults with primary FSGS treated with cyclosporine A (CsA).
It includes patients histologically proven FSGS and managed in the Charles Nicolle Hospital at Tunis, Tunisia.
The dose of CsA was adjusted to maintain a whole blood trough level of 80–150 ng/mL.
The observation period was 6.8 ± 3.7 years after CsA treatment.
Twenty-three patients with idio- pathic FSGS, treated with CsA, were studied.
The mean age was 26.69 ± 10.1 years, and the sex ratio was 2.83.
Eight patients (35%) had a steroid-dependent nephrotic syndrome (NS), and 15 patients (65%) had for steroid-resistant NS.
After a median follow-up of 16.5 months on CsA, we noticed complete remission of the NS in eight cases (35%) after 12.12 ± 8 months, partial remis- sion in five (22%) after 3 ± 0.7 months, dose-dependent remission to CsA (2.87 mg/kg/day) in four (17%), and a no response in six patients (26%).
Eleven patients (48%) showed improvement of renal function, while eight (35%) developed end-stage renal disease (ESRD) after 35.7 ± 20.9 months.
Predictive factors of progression to ESRD were creatinine clearance <90 mL/min before introduction of CsA (P = 0.0054) and CsA-resistance (P = 0.053).
Our study suggests that CsA is effective in the treatment of patients with idiopathic FSGS.
Initial renal function and cyclosporineresistance are the predictive factors of ESRD in steroid-resistant or -dependent FSGS.
American Psychological Association (APA)
Gorsane, Imen& Hilal, I.& Yaqub, I.& Bin Hamidah, F.& Abd al-Rahim, E.& Ibn Abd Allah, T.. 2016. Cyclosporine therapy in steroid-dependent or steroid-resistant idiopathic focal and segmental glomerulosclerosis. Saudi Journal of Kidney Diseases and Transplantation،Vol. 27, no. 5, pp.958-965.
https://search.emarefa.net/detail/BIM-717095
Modern Language Association (MLA)
Gorsane, Imen…[et al.]. Cyclosporine therapy in steroid-dependent or steroid-resistant idiopathic focal and segmental glomerulosclerosis. Saudi Journal of Kidney Diseases and Transplantation Vol. 27, no. 5 (Sep. / Oct. 2016), pp.958-965.
https://search.emarefa.net/detail/BIM-717095
American Medical Association (AMA)
Gorsane, Imen& Hilal, I.& Yaqub, I.& Bin Hamidah, F.& Abd al-Rahim, E.& Ibn Abd Allah, T.. Cyclosporine therapy in steroid-dependent or steroid-resistant idiopathic focal and segmental glomerulosclerosis. Saudi Journal of Kidney Diseases and Transplantation. 2016. Vol. 27, no. 5, pp.958-965.
https://search.emarefa.net/detail/BIM-717095
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 963-965
Record ID
BIM-717095