Evaluation of the diuretic and urinary electrolyte effects of methanolic extract of Peganum harmala l. in Wistar albino rats
Joint Authors
al-Saykhan, Fahd I.
al-Ansari, Muhammad N.
Source
Saudi Journal of Biological Sciences
Issue
Vol. 23, Issue 6 (30 Nov. 2016), pp.749-753, 5 p.
Publisher
Publication Date
2016-11-30
Country of Publication
Saudi Arabia
No. of Pages
5
Main Subjects
Pharmacy, Health & Medical Sciences
Medicine
Abstract EN
The use of traditional medicines as a diuretic agent has been increasing in recent years.
The diuretic activity of a number of plant extracts used as diuretic agents in ethnomedicine has been confirmed in experimental animals.
However, despite the widespread use of Peganum harmala in traditional medicine, there is a paucity of data supporting its use as a diuretic agent.
Therefore, the present study aimed to envisage the true effect and magnitude of diuresis of methanolic extract of P.
harmala (MEPH) in comparison with a well-known diuretic drug furosemide using Wistar albino rats.
MEPH was administered orally in three different doses (150, 300 and 450 mg/kg) to experimentally dehydrated rats.
Furosemide (10 mg/kg orally) was used as a reference drug.
The diuretic effect of the MEPH was evaluated by measuring urine volume, urine pH, urinary electrolyte levels, natriuretic and saliuretic effects.
The urine volume (in mL) measured at 5 h and 24 h and electrolyte excretion (Na+, K+, and Cl _ ) at 24 h duration were measured.
The urine output and urinary electrolyte excretion were found to be significantly higher in rats treated with MEPH as compared to normal rats in a dose dependent manner (P < 0.05).
The results of our study were comparable to furosemide drug.
Based on observed results, we can recommend that P.
harmala may be an effective diuretic, however, toxicity studies should be conducted before administration.
_ 2016 The Authors.
Production and hosting by Elsevier B.V.
on behalf of King Saud University.
This is an open access article under theCCBY-NC-NDlicense (http://creativecommons.org/licenses/by-nc-nd/4.0/).
American Psychological Association (APA)
al-Saykhan, Fahd I.& al-Ansari, Muhammad N.. 2016. Evaluation of the diuretic and urinary electrolyte effects of methanolic extract of Peganum harmala l. in Wistar albino rats. Saudi Journal of Biological Sciences،Vol. 23, no. 6, pp.749-753.
https://search.emarefa.net/detail/BIM-717173
Modern Language Association (MLA)
al-Saykhan, Fahd I.& al-Ansari, Muhammad N.. Evaluation of the diuretic and urinary electrolyte effects of methanolic extract of Peganum harmala l. in Wistar albino rats. Saudi Journal of Biological Sciences Vol. 23, no. 6 (Nov. 2016), pp.749-753.
https://search.emarefa.net/detail/BIM-717173
American Medical Association (AMA)
al-Saykhan, Fahd I.& al-Ansari, Muhammad N.. Evaluation of the diuretic and urinary electrolyte effects of methanolic extract of Peganum harmala l. in Wistar albino rats. Saudi Journal of Biological Sciences. 2016. Vol. 23, no. 6, pp.749-753.
https://search.emarefa.net/detail/BIM-717173
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 752-753
Record ID
BIM-717173