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Antioxidant effects of captopril against lead acetate-induced hepatic and splenic tissue toxicity in Swiss albino mice
Joint Authors
al-Dahmash, Badr A.
al-Najjar, Dua M.
Source
Saudi Journal of Biological Sciences
Issue
Vol. 23, Issue 6 (30 Nov. 2016), pp.667-673, 7 p.
Publisher
Publication Date
2016-11-30
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Pharmacy, Health & Medical Sciences
Medicine
Abstract EN
Considering that lead caused a lot of health problems in the world, the present study was carried out to investigate the protective effect of captopril as antioxidants to reduce liver and spleen toxicity induced by lead.
Animals were divided into 3 groups, the 1st group served as control group, the 2nd group received 20 mg/kg of lead acetate and the 3rd group received 50 mg/kg of captopril one hour prior to lead administration for 5 days.
Results showed that lead intake caused severe alterations in the liver and spleen manifested by hepatocytes degeneration, leukocytic infiltration, fibrosis in liver and moderate to severe liver pathological score.
Spleen showed ill-defined architecture, presence of large macrophages and lymphoid necrosis.
Administration of captopril reduced hepatotoxicity, liver fibrosis and decrease in pathological scoring system.
Moreover, reduced toxicity in spleen is represented by reduction in necrotic areas, more or less healthy lymphoid follicles and decreasing in pathological scoring system.
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American Psychological Association (APA)
al-Dahmash, Badr A.& al-Najjar, Dua M.. 2016. Antioxidant effects of captopril against lead acetate-induced hepatic and splenic tissue toxicity in Swiss albino mice. Saudi Journal of Biological Sciences،Vol. 23, no. 6, pp.667-673.
https://search.emarefa.net/detail/BIM-717185
Modern Language Association (MLA)
al-Dahmash, Badr A.& al-Najjar, Dua M.. Antioxidant effects of captopril against lead acetate-induced hepatic and splenic tissue toxicity in Swiss albino mice. Saudi Journal of Biological Sciences Vol. 23, no. 6 (Nov. 2016), pp.667-673.
https://search.emarefa.net/detail/BIM-717185
American Medical Association (AMA)
al-Dahmash, Badr A.& al-Najjar, Dua M.. Antioxidant effects of captopril against lead acetate-induced hepatic and splenic tissue toxicity in Swiss albino mice. Saudi Journal of Biological Sciences. 2016. Vol. 23, no. 6, pp.667-673.
https://search.emarefa.net/detail/BIM-717185
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 672-673
Record ID
BIM-717185