Toxicity of silver nanoparticles on the brain of Oreochromis niloticus and Tilapia zillii
Joint Authors
Afifi, Muhammad
Abu Zinada, Usamah
Saddick, Salina Y.
Source
Saudi Journal of Biological Sciences
Issue
Vol. 23, Issue 6 (30 Nov. 2016), pp.1-7, 7 p.
Publisher
Publication Date
2016-11-30
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Pharmacy, Health & Medical Sciences
Medicine
Abstract EN
Background : Silver nanoparticles (Ag-NPs) are widely used nowadays in a variety of commercial applications including medical, health care, textiles and household supplies.
Objectives : The current study was designed to determine the median lethal dose (LC50) of Ag-NPs on Oreochromis niloticus and Tilapia zillii.
Methods : Acute and sub-acute toxicity study of the Ag-NPs on brain tissues was carried out using different concentrations of the NPs at 2 mg L and 4 mg L.
These concentrations were dispersed in deionized water with the exception of the control groups in the experiments.
Biochemical and molecular analysis were conducted on tissue homogenates in order to evaluate the potential effects of NPs on the antioxidant system.
Results : The Ag-NP acute toxicity (96 h LC50) values of 19.5 ± 2 and 20 ± 2.4 mg / L were reported for O.
niloticus and T.
zillii respectively.
Fish exposed to 2 mg/L Ag-NPs did not show any significant change in the levels of reduced glutathione (GSH), total glutathione (tGSH) levels, superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), glutathione peroxidase (GPx) and glutathione-S-transferase (GST) activity or genes expression and malondialdehyde (MDA) level.
In contrary, a dose of 4 mg/L showed a significant reduction in the levels all the above-mentioned parameters except in MDA level where it was significantly induced.
Conclusion: Results indicate that exposure of O.
niloticus and T.
zillii to Ag-NPs (4 mg / L) has deleterious effects on brain antioxidant system, whereas a dose of 2 mg / L has no effects.
_ 2016 The Authors.
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This is an open access article under theCCBY-NC-NDlicense (http://creativecommons.org/licenses/by-nc-nd/4.0/).
American Psychological Association (APA)
Afifi, Muhammad& Saddick, Salina Y.& Abu Zinada, Usamah. 2016. Toxicity of silver nanoparticles on the brain of Oreochromis niloticus and Tilapia zillii. Saudi Journal of Biological Sciences،Vol. 23, no. 6, pp.1-7.
https://search.emarefa.net/detail/BIM-717189
Modern Language Association (MLA)
Afifi, Muhammad…[et al.]. Toxicity of silver nanoparticles on the brain of Oreochromis niloticus and Tilapia zillii. Saudi Journal of Biological Sciences Vol. 23, no. 6 (Nov. 2016), pp.1-7.
https://search.emarefa.net/detail/BIM-717189
American Medical Association (AMA)
Afifi, Muhammad& Saddick, Salina Y.& Abu Zinada, Usamah. Toxicity of silver nanoparticles on the brain of Oreochromis niloticus and Tilapia zillii. Saudi Journal of Biological Sciences. 2016. Vol. 23, no. 6, pp.1-7.
https://search.emarefa.net/detail/BIM-717189
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 6-7
Record ID
BIM-717189