Vaccination against Corynebacterium pseudotuberculosis infections controlling caseous lymphadenitis (CLA) and oedematousskin disease
Joint Authors
Husayn, Ashjan Muhammad
Musa, Ihab Muhammad
Qabli, Salih A.
Salim, Salihah Abd al-Karim
Hemeg, Hassan Abd Allah
Ali, Muhammad S.
Source
Saudi Journal of Biological Sciences
Issue
Vol. 23, Issue 6 (30 Nov. 2016), pp.718-723, 6 p.
Publisher
Publication Date
2016-11-30
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Pharmacy, Health & Medical Sciences
Medicine
Abstract EN
Corynebacterium pseudotuberculosis (C.
pseudotuberculosis) is a causative organism of caseous lymphadenitis (CLA) in sheep and acute disease in buffaloes known as oedematous skin disease (OSD).
Human affected with the disease show liver abscess and abscess in the internal lymph nodes.
The vaccination against CLA up till now occurs by using formalin inactivated whole cells of biovar 1 (sheep strain).
Combined vaccine composed of formalin inactivated whole cells of sheep strain and recombinant phospholipase D (rPLD) and another vaccine composed of formalin inactivated whole cells (buffalo origin) and rPLD were prepared in Biotechnology center for services and Researches laboratory at Cairo university and applied for protection against CLA.
Both vaccines induced complete protection (100%) against challenge with virulent biovar 1 or biovar 2.
Also vaccination against OSD was performed by two types of vaccines.
Vaccine-1 was composed of formalin inactivated whole cell biovar 1 combined with rPLD and the second vaccine was composed of formalin inactivated whole cells of biovar 2 combined with rPLD.
No lesions developed in vaccinated and non vaccinated buffaloes challenged with C.
pseudotuberculosis biovar revealing that biovar 1 C.
pseudotuberculosis is not infective for buffaloes.
Buffaloes vaccinated with the second vaccine and control non vaccinated animals challenged with biovar 2 (buffalo origin) resulted in development of OSD in all animals.
This indicates that OSD results due to production of toxin (s) other than PLD.
Discovering this toxin (s) is of value in formulation of a future vaccine against OSD.
_ 2016 The Authors.
Production and hosting by Elsevier B.V.
on behalf of King Saud University.
This is an open access article under theCCBY-NC-NDlicense (http://creativecommons.org/licenses/by-nc-nd/4.0/).
American Psychological Association (APA)
Musa, Ihab Muhammad& Ali, Muhammad S.& Husayn, Ashjan Muhammad& Qabli, Salih A.& Hemeg, Hassan Abd Allah& Salim, Salihah Abd al-Karim. 2016. Vaccination against Corynebacterium pseudotuberculosis infections controlling caseous lymphadenitis (CLA) and oedematousskin disease. Saudi Journal of Biological Sciences،Vol. 23, no. 6, pp.718-723.
https://search.emarefa.net/detail/BIM-717191
Modern Language Association (MLA)
Ali, Muhammad S.…[et al.]. Vaccination against Corynebacterium pseudotuberculosis infections controlling caseous lymphadenitis (CLA) and oedematousskin disease. Saudi Journal of Biological Sciences Vol. 23, no. 6 (Nov. 2016), pp.718-723.
https://search.emarefa.net/detail/BIM-717191
American Medical Association (AMA)
Musa, Ihab Muhammad& Ali, Muhammad S.& Husayn, Ashjan Muhammad& Qabli, Salih A.& Hemeg, Hassan Abd Allah& Salim, Salihah Abd al-Karim. Vaccination against Corynebacterium pseudotuberculosis infections controlling caseous lymphadenitis (CLA) and oedematousskin disease. Saudi Journal of Biological Sciences. 2016. Vol. 23, no. 6, pp.718-723.
https://search.emarefa.net/detail/BIM-717191
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 723
Record ID
BIM-717191