Serum levels of N-terminal-pro B-type natriuretic peptide as a diagnostic marker for left ventricular dysfunction in children with end-stage renal disease on hemodialysis

Abstract EN

The objective of this study was to determine the diagnostic cutoff value of Nterminal- pro B-type natriuretic peptide (NT-pro BNP) as a marker of left ventricular (LV) dysfunction in children with end-stage renal disease (ESRD) on regular hemodialysis (HD).

The study was carried out on thirty children with ESRD on regular HD and thirty healthy controls.

Echocardiographic studies were done, including a conventional mode for ejection fraction, fractional shortening, tissue Doppler imaging, and longitudinal global strain by speckle tracking.

Serum levels of NT-pro BNP were measured in venous blood samples before and about 30 min after HD by ELISA.

Volume status was assessed by calculating interdialytic weight gain %.

There were significant higher serum NT-pro BNP levels before HD (mean : 702.3 ± 274.3 ng / L) compared to controls (mean: 365.55 ± 76.5 ng / L) (P < 0.001) and these levels decreased significantly after the HD session (mean : 625.1 ± 117.69 ng / L) (P = 0.031).

Echocardiographic