Misoprostol use in medical evacuation of spontaneous miscarriage : pilot drug use evaluation study at the women’s hospital in Qatar
Joint Authors
al-Said, Doua T.
Abd al-Rauf, Palli V.
Ahmad, Afif A.
al-Hail, Muza S.
al-Salim, Salih
Source
Issue
Vol. 25, Issue 1 (30 Jun. 2016), pp.1-8, 8 p.
Publisher
Publication Date
2016-06-30
Country of Publication
Qatar
No. of Pages
8
Main Subjects
Topics
Abstract EN
Background : Misoprostol is a synthetic prostaglandin E1 that induces cervical effacement and uterine contractions at all gestational ages, thus facilitating uterine evacuation and pregnancy termination.
Successful medical evacuation of spontaneous miscarriage with minimal adverse effects can be performed using misoprostol-only regimen if given as indicated and if the administered dose, frequency of the dosage, and number of total doses are appropriate.
Aim: To conduct a drug use evaluation by investigating indications, appropriateness of dosing, and clinical outcome of misoprostol-only regimen when used for medical evacuation of spontaneous miscarriage at the Women’s Hospital in Doha, Qatar.
Materials and methods: A retrospective descriptive drug use evaluation was conducted on women with spontaneous miscarriage who received misoprostol for medical evacuation during August 2013.
The current practice at the Women’s Hospital was compared with the recommendation from the World Health Organization (WHO).
Patients were stratified into three groups based on weeks of amenorrhea.
Results: A total of 107 patients received misoprostol during August 2013, of which 33 (31%) were included in the study.
In these patients, the main indication for misoprostol use was missed miscarriage (54.5%).
In the group of patients at #9 weeks of gestation, 80% received an initial dose of 800mg, 80% received frequency within the WHO recommendation, and the majority had surgical evacuation (80 %).
In the group of patients at 10–12 weeks of gestation, more than 80% received an initial dose of 800mg, 6% received frequency within the WHO recommendation, and more than 75 % had successful medical evacuation.
In the group of patients at 13–22 weeks of gestation, more than 80 % received an initial dose of 400mg, more than 80 % received frequency within the WHO recommendation, and 54 % had successful medical evacuation.
Overall, more than 70 % of the patients received #3 total doses of misoprostol and more than 60% had successful medical evacuation as a clinical outcome.
Conclusions : Despite the current practice at the Women’s Hospital not always being in accordance with the WHO recommendation, successful medical evacuation was achieved in most patients.
American Psychological Association (APA)
al-Salim, Salih& al-Said, Doua T.& Abd al-Rauf, Palli V.& Ahmad, Afif A.& al-Hail, Muza S.. 2016. Misoprostol use in medical evacuation of spontaneous miscarriage : pilot drug use evaluation study at the women’s hospital in Qatar. Qatar Medical Journal،Vol. 25, no. 1, pp.1-8.
https://search.emarefa.net/detail/BIM-717975
Modern Language Association (MLA)
al-Salim, Salih…[et al.]. Misoprostol use in medical evacuation of spontaneous miscarriage : pilot drug use evaluation study at the women’s hospital in Qatar. Qatar Medical Journal Vol. 25, no. 1 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-717975
American Medical Association (AMA)
al-Salim, Salih& al-Said, Doua T.& Abd al-Rauf, Palli V.& Ahmad, Afif A.& al-Hail, Muza S.. Misoprostol use in medical evacuation of spontaneous miscarriage : pilot drug use evaluation study at the women’s hospital in Qatar. Qatar Medical Journal. 2016. Vol. 25, no. 1, pp.1-8.
https://search.emarefa.net/detail/BIM-717975
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 7-8
Record ID
BIM-717975