دراسة حول تواتر أضداد p53 الذاتية لدى مرضى التهاب الكبد في سورية
Other Title(s)
a study about the frequency of p53 autoantibodies in Syrian hepatitis patients
Joint Authors
Source
Issue
Vol. 6, Issue 3 (31 Oct. 2011)
Publisher
Syrian Clinical Laboratory Association
Publication Date
2011-10-31
Country of Publication
Syria
Main Subjects
Abstract EN
The aim of the study was to determine the frequency of anti-p53 antibodies in the serums of viral hepatitis, auto-immune hepatitis and hepatocellular carcinoma (HCC) patients in Syria, and comparing anti-p53 antibodies with αFetoprotein (AFP) tumor marker that used in a routine way in HCC patients, so it conclude the promising benefit of participant detection of these two markers in earlier detection of chronic hepatitis development states to hepatocellular carcinoma (HCC), subsequently the earlier remedy possibility which achieve longer life for these patients.
Anti-p53 antibodies in serums of 50 hepatitis C, 30 hepatitis B, 40 HCC, 10 auto-immune hepatitis patients and 35 of the control group had been analyzed by using ELISA assay.
The account of positive patients was 2, 0, 8, 2, 0 respectively, and the difference was statistically significant (P<0.05).
The presence of anti-p53 was independent of AFP status, in contrast to AFP, which is more likely to be positive in large tumors, the antibodies were detectable in a substantial proportion of small HCCS and and this suggests that anti-p53 could be valuable in scanning tests for tumor patients.
So from this we conclude that, if AFP and anti p53 results are combined this would increase sensitivity and specificity of detection.
American Psychological Association (APA)
نور الدين نوح والصالح، جمانة. 2011. دراسة حول تواتر أضداد p53 الذاتية لدى مرضى التهاب الكبد في سورية. مجلة التشخيص المخبري،مج. 6، ع. 3.
https://search.emarefa.net/detail/BIM-718520
Modern Language Association (MLA)
نور الدين نوح والصالح، جمانة. دراسة حول تواتر أضداد p53 الذاتية لدى مرضى التهاب الكبد في سورية. مجلة التشخيص المخبري مج. 6، ع. 3 (تشرين الأول 2011).
https://search.emarefa.net/detail/BIM-718520
American Medical Association (AMA)
نور الدين نوح والصالح، جمانة. دراسة حول تواتر أضداد p53 الذاتية لدى مرضى التهاب الكبد في سورية. مجلة التشخيص المخبري. 2011. مج. 6، ع. 3.
https://search.emarefa.net/detail/BIM-718520
Data Type
Journal Articles
Language
Arabic
Notes
يتضمن مراجع ببليوجرافية
Record ID
BIM-718520