Cocaine-like discriminative stimulus effects of mephedrone and naphyrone in mice
Joint Authors
Gannon, Brenda M.
Fantegrossi, William E.
Source
Journal of Drug and Alcohol Research
Issue
Vol. 5, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Publication Date
2016-12-31
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Social Sciences (Multidisciplinary)
Medicine
Abstract EN
Background.
In recent years, commercial bath salts products containing synthetic cathinone analogues have emerged as illicit drugs of abuse.
These cathinones are structurally similar to the psychostimulants 3,4-methylenedioxymethamphetamine (MDMA) and methamphetamine (METH), and produce their effects via interactions with monoamine transporters, where smaller compounds (e.g., mephedrone) are amphetamine-like monoamine releasers, while the structurally larger compounds (e.g., naphyrone) are cocaine-like monoamine reuptake inhibitors.
Individual cathinones also differ from one another with respect to selectivity among the three monoamine transporters.
Statement of purpose of study.
This study was designed to assess the cocaine-like interoceptive effects of synthetic cathinone analogues functioning as passive monoamine reuptake inhibitors (naphyrone) or as releasers (mephedrone) in mice in order to compare effectiveness (degree of substitution) and potency with positive control psychostimulants cocaine, METH, and MDMA.
Procedures.
In the present study, mice were trained to discriminate 10 mg/kg cocaine from saline, and substitutions with METH, MDMA, mephedrone, naphyrone, and morphine were performed.
Main findings.
Mice reliably discriminated the cocaine training dose from saline, and METH, MDMA, mephedrone, and naphyrone all elicited full cocainelike responding, while morphine did not.
Potency differences were observed such that METH was most potent, while mephedrone, cocaine, MDMA, and naphyrone exhibited roughly equivalent potency.
Principal conclusions.
These data confirm that interaction with DAT is an important component of cocaine-like discriminative stimulus effects, and suggest that synthetic-
American Psychological Association (APA)
Gannon, Brenda M.& Fantegrossi, William E.. 2016. Cocaine-like discriminative stimulus effects of mephedrone and naphyrone in mice. Journal of Drug and Alcohol Research،Vol. 5, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-721640
Modern Language Association (MLA)
Gannon, Brenda M.& Fantegrossi, William E.. Cocaine-like discriminative stimulus effects of mephedrone and naphyrone in mice. Journal of Drug and Alcohol Research Vol. 5 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-721640
American Medical Association (AMA)
Gannon, Brenda M.& Fantegrossi, William E.. Cocaine-like discriminative stimulus effects of mephedrone and naphyrone in mice. Journal of Drug and Alcohol Research. 2016. Vol. 5, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-721640
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 4-5
Record ID
BIM-721640