Synthesis and characterization of some new pyrazoline and isoxazoline derivatives as antibacterial agents

Abstract EN

In this paper some chalcones (C1-C8) are prepared based on the reaction of one mole of substituted acetophenone with one mole of substituted benzaldehydes in the presence of (40%) sodium hydroxide as a base.

Pyrazolines (P1–P8) are prepared from the reaction of chalcones (C1-C8) with hydrazine hydrate.

Isoxazoline (I1-I8) is prepared from the reaction of chalcones (C1-C8) with hydroxyl amine hydrochloride in the presence of (10%) sodium hydroxide as a base.

These compounds are characterized by using various physical and spectral methods.

The compounds are screened for their in vitro antibacterial activity using grampositive bacteria and gram-negative bacteria.

Several derivatives of pyrazolines and isoxazolines are produced well to moderate activities against number of bacteria.