Thrombophilic mutations in blood donors in Duhok Iraq
Other Title(s)
الطفرات الوراثية لفرط التخثر في متبرعي الدم في دهوك-العراق
Joint Authors
Jibrail, Jaladat M. S.
Baban, Nawras K.
Gedeon, George S.
al-Allawi, Nasir A. S.
Source
Issue
Vol. 3, Issue 1 (30 Jun. 2009), pp.25-32, 8 p.
Publisher
University of Duhok College of Medicine
Publication Date
2009-06-30
Country of Publication
Iraq
No. of Pages
8
Main Subjects
Abstract EN
Background Thrombophilia is a multifactorial disease due to the interplay between acquired and inherited factors.
Factor V Leiden (G1691A), Prothrombin (G20210A) and MTHFR (C677T) are among the important inherited causes.
The prevalence of these three thrombophilic mutations has not been addressed collectively in Iraqis, including the population of Duhok.
Objectives Determine the prevalence of thrombophilic mutations among healthy blood donors from Duhok.
Materials and Methods One hundred and fifty random healthy blood donors from the regional blood bank in Duhok-Iraq were investigated using multiplex PCR and reverse hybridization to oligonucleotide specific probes to detect Factor V leiden and MTHFR C677T mutations.
While the first hundred donors were also screened using the same technology for Prothrombin G20210A mutation.
Results Factor V Leiden and Prothrombin G20210A carrier states were found in 1.25% and 3% of the individuals screened for them, respectively.
The MTHFR C677T homozygous and heterozygous states were confirmed in 8 and 44% respectively.
Conclusions This study demonstrated that while the prevalence of Prothrombin and MTHFR mutations were rather consistent with pattern seen in surrounding countries in the Mediterranean region, Factor V Leiden prevalence was the least ever reported from any other population in the region.
The latter finding suggests that the contribution of Factor V leiden to thrombotic states in Northern Iraq may not be as significant as it is in other countries in the region.
American Psychological Association (APA)
al-Allawi, Nasir A. S.& Jibrail, Jaladat M. S.& Baban, Nawras K.& Gedeon, George S.. 2009. Thrombophilic mutations in blood donors in Duhok Iraq. Duhok Medical Journal،Vol. 3, no. 1, pp.25-32.
https://search.emarefa.net/detail/BIM-722788
Modern Language Association (MLA)
al-Allawi, Nasir A. S.…[et al.]. Thrombophilic mutations in blood donors in Duhok Iraq. Duhok Medical Journal Vol. 3, no. 1 (2009), pp.25-32.
https://search.emarefa.net/detail/BIM-722788
American Medical Association (AMA)
al-Allawi, Nasir A. S.& Jibrail, Jaladat M. S.& Baban, Nawras K.& Gedeon, George S.. Thrombophilic mutations in blood donors in Duhok Iraq. Duhok Medical Journal. 2009. Vol. 3, no. 1, pp.25-32.
https://search.emarefa.net/detail/BIM-722788
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 29-30
Record ID
BIM-722788