Anti- β2-glycoprotein I autoantibodies more correlates with strokes in antiphospholipid syndrome

Abstract EN

Objectives To determine the significance of testing for anit-beta-2 glycoprotein I dependent (aβ2-GPI) among stroke patients of antiphospholipid syndrome (APS).

Subjects and Methods Fifty selected patients with strokes and 30 healthy individuals were tested for IgG isotype of anticardiolipin (aCL), aβ 2-GPI, and antiphosphatidyl serine (aPS) autoantibodies.

The study was conducted in the Postgraduate Laboratory Center, College of Medicine, and University of Dohuk, Iraq during April 2005.

The indirect solid phase enzyme – linked immuno-sorbent assay (ELISA) technique was used for the detection of IgG aCL, aβ 2-GPI, and aPS.

The studied cases and controls were under 50 years of age and had no recognizable risk factors.

Results One or more of the tested APLAs were detected in 14/50 (28%) of cases with stroke.

The IgG aCL was detected in 11/50 (22%), IgG aβ 2-GPI in 14/50 (28%), and IgG aPS in 9/50 (18%) of the studied patients.

However, IgG aCL was detected in 2/30 (6.7%) of controls with absence of other antiphospholipids antibodies (APLAs).

All IgG aPS positive cases (9/14, 18%) were found to be positive for IgG aβ2-GPI and IgG aCL markers.

Moreover, all IgG aCL positive cases (11/50, 22%) were positive for IgG aβ2-GPI marker.

On the other hand, IgG aβ2-GPI as a sole marker was detected in another 3 positive APLAs cases with (3/14, 21.4%).

Conclusions In this study, IgG aβ2-GPI autoantibodies were found to correlate more with stroke cases of APS than other APLAs.

These findings necessitate testing for this marker and ascertain the evidence accumulating which would assign a central role played by aβ2-GPI in strokes of APS.