Influence of turmeric on biochemical disorders induced by exposure to γ-rays or chlorpyrifos pesticide on rats

Abstract EN

Toxicity of Chlorpyrifos and γ-radiation exposure on rats were examined in the presence or absence of Turmeric (200 mg/ kg/ b.wt.).

Effects chlorpyrifos when administrated orally to rats at a dose 9 mg/ kg b .wt (1/ 4 LD50) for 7 and 28 days showed increased level of malondialdehyde (MDA) concomitant with depletion in the levels of glutathion (GSH), superoxide dismutase (SOD) and catalase (CAT).γ-radiation exposure effect on rats was examined in the presence or absence of turmeric .

Exposure of rats to γ-radiation (8 Gy) at a fractionated dose levels (2 Gy/ week for 4 weeks) exhibited an elevated level of MDA and decreased level of GSH, SOD and CAT.

Administration of Turmeric to animals which were previously treated with Chlorpyrifose or γ-rays showed an amelioration response to the antioxidant regime.

Treatment of rats with Chlorpyrifose for 7and 28 days or γ-radiation induced an elevated serum transaminases level(ALT&AST),Alkaline phosphatase (ALP) and Acid phosphatase activitey (ACP), creatinine concentration, blood urea and uric acid.Also treatment of rats with Chlorpyrifose for 7and 28 days or γ-radiation induced a decline in the testosterone level associated with alteration in the levels of follicular stimulating hormone (FSH),Iuetinizing hormone (LH) and prolactin (PRL).Results observed due to Chlorpyrifose pesticide or radiation-exposure have been ameliorated by turmeric administration.

It could be concluded that turmeric might protect from oxidative stress.