Efficiency of broccoli in attenuating of some biochemical disorders in rats exposed to γ-irradiation

Abstract EN

Administration of dietary antioxidants has been suggested to protect against ionizing radiation induced injury.

Broccoli is a floral vegetable with an important nutritional value due to its content of antioxidants and anti-carcinogenic compounds.

Thus, the aim of this study was oriented to study the ameliorative effect of broccoli administration against γ-radiation induced oxidative stress.

Exposure of rats to γ-radiation (6 Gy) induce a significant increase in the level of malondialdehyde (MDA) and hepatic xanthine oxidase (XO) activity, the concentration of some lipid contents, the activity of some liver enzymes and glucose concentration.

Whereas, the value of hepatic glutathion content and the activity of hepatic xanthine dehydrogenase (XDH), superoxides dismutase (SOD) and catalase (CAT) activity, high-density lipoprotein-cholesterol (HDL-C) concentration and the level of insulin and testosterone were significantly decreased.

On the other hand, dietary supplementation with broccoli to γ-irradiated rats resulted in an obvious amelioration of the hazardous effects induced by γ-irradiation.

In conclusion, the results suggested that broccoli has remarkable radioprotective effects against radiation induced oxidative damage and that might be attributed to its phytochemical contents.