Second malignant neoplasms after radio-chemotherapy of Hodgkin’s lymphoma

Abstract EN

The objective of this study is to identify the second malignant neoplasms (SMNs) after treatment of Hodgkin’s lymphoma (HL)in long-term survivors (LTS) of Hodgkin’s disease (HD) patients who were regularly attending the pediatric oncology clinic of National Cancer Institute (NCI).

42 LTS were studied.

During 3 years period, all patients subjected to through clinical history/ examination.

Files were revised for date of diagnoses, original site(s), stage, histopathological subtypes and dose/ duration of therapy.

Clinical examination was done with laying stress on blood pressure, pulse, chest &cardiac examination, visceromegaly and the presence of lymphadenopathy.

Lab investigations included CBC, ESR and bone marrow aspirate &/or biopsy.

Radiodiagnostic studies were done whenever indicated.

One LTS had acute myeloid leukemia [AML] as a second malignant neoplasm.

Finally, the study documented the risk of secondary malignancy [AML] was one of the long-term sequelae of radio-chemotherapy in HD patients.

Recommendations regarding the follow-up of therapy for HD and Screening for early detection of late effects were discussed.

New strategies with reduction or elimination of radiation dose are needed for dealing with HD, especially in children.