Evaluation of radio protective effects of coriander (Coriandrum sativum L.)‎ in male rats

Abstract EN

Radiation is one of the most widespread sources of environmental stress in living environment which cause oxidative stress and metabolic changes.

The basic purpose of this work was to determine the radio protective ability of Coriander (Coriandrum sativum L.) seeds against whole body gamma irradiation of rats.

The study was conducted on thirty two male rats which were classified into four equal groups.

Control group: (normal, untreated).

Coriander aqueous extract group (C.E.): rats received orally by gavage the aqueous extract of Corianderseed powder (300 mg/ kg b.

wt.

/ day for 42 days).

Irradiated group: rats were subjected to whole body ?–irradiation at dose of 4 Gy delivered as a single exposure dose.

Combined treatment group: rats received orally C.E.

(300 mg/ kg b.

wt.

/ day) for 42 days?at day 35 of C.E.

treatment the rats were irradiated at dose level of 4 Gy.

The animals exposed to gamma radiation showed a significant increase in serum aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH), urea (U), creatinine (Cr), total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C) and tissue thiobarbituric acid reactive substance (TBARS).

On the other hand, a significant decrease was recorded in serum total protein (T.P), albumin (Alb), high density lipoprotein cholesterol (HDL-C).

A decrease of liver and kidney reduced glutathione (GSH) content, superoxides dismutase (SOD) and catalase (CAT) activities were reported.

Treatment of rats with C.E.

significantly reduced the radiation-induced serum biochemical disorders which was associated with significant amelioration in the oxidant / antioxidant status of liver and kidney tissues.

It could be concluded that C.E.

might protect from radiation induced damage due to its ability to scavenge free radicals.