Salvia officinalis l. (sage) ameliorates radiation-induced oxidative brain damage in rats
Joint Authors
Abd al-Azim, A. Sh.
Uthman, N. N.
Source
Arab Journal of Nuclear Sciences and Applications
Issue
Vol. 46, Issue 1 (31 Jan. 2013), pp.297-304, 8 p.
Publisher
The Egyptian Society of Nuclear Science and Applications
Publication Date
2013-01-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The present study was designed to investigate the oxidative stress and the role of antioxidant system in the management of gamma irradiation induced whole brain damage in rats .
Also, to elucidate the potential role of Salvia officinalis (sage) in alleviating such negative effects.
Rats were subjected to gamma radiation (6 Gy).
Sage extract was daily given to rats during 14 days before starting irradiation and continued after radiation exposure for another 14 days.
The results revealed that the levels of thiobarbituric acid reactive substances (TBARS), protein carbonyl content (PCC) and nitric oxide (NO) content were significantly increased, while the activities of superoxide dismutase (SOD) and catalase (CAT) as well as the reduced glutathione (GSH) content were significantly decreased in the brain homogenate of irradiated rats.
Additionally, brain acetylcholinesterase (AChE) as well as alkaline phosphatase (ALP), acid phosphatase (ACP) and lactate dehydrogenase (LDH) activities were significantly increased.
On the other hand, the results showed that, administration of sage extract to rats was able to ameliorate the mentioned parameters and the values returned close to the normal ones.
It could be concluded that sage extract, by its antioxidant constituents, could modulate radiation –induced oxidative stress and enzyme activities in the brain.
American Psychological Association (APA)
Uthman, N. N.& Abd al-Azim, A. Sh.. 2013. Salvia officinalis l. (sage) ameliorates radiation-induced oxidative brain damage in rats. Arab Journal of Nuclear Sciences and Applications،Vol. 46, no. 1, pp.297-304.
https://search.emarefa.net/detail/BIM-724102
Modern Language Association (MLA)
Uthman, N. N.& Abd al-Azim, A. Sh.. Salvia officinalis l. (sage) ameliorates radiation-induced oxidative brain damage in rats. Arab Journal of Nuclear Sciences and Applications Vol. 46, no. 1 (Jan. 2013), pp.297-304.
https://search.emarefa.net/detail/BIM-724102
American Medical Association (AMA)
Uthman, N. N.& Abd al-Azim, A. Sh.. Salvia officinalis l. (sage) ameliorates radiation-induced oxidative brain damage in rats. Arab Journal of Nuclear Sciences and Applications. 2013. Vol. 46, no. 1, pp.297-304.
https://search.emarefa.net/detail/BIM-724102
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 302-304
Record ID
BIM-724102