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Royal jelly modulates hepatotoxic effect of rats treated with cisplatin
Joint Authors
Source
Arab Journal of Nuclear Sciences and Applications
Issue
Vol. 47, Issue 1 (28 Feb. 2014), pp.172-180, 9 p.
Publisher
The Egyptian Society of Nuclear Science and Applications
Publication Date
2014-02-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Cisplatin (CP) is one of the most active cytotoxic agents in the treatment of cancer and has adverse side effects such as hepatotoxicity and nephrotoxicity.
The aim of this study was focused on investigating the possible protective effect of royal jelly (RJ) against oxidative stress caused by CP injury of the liver and inflammatory changes in male albino rats.
Twenty four albino rats were divided into four equal groups as follows: control group, cisplatin group : (rats injected i.p.
with single dose from cisplatin (CP, 7 mg / kg body weight,), royal jelly RJ group : rats treated for 15 consecutive days by gavage with RJ (300 mg/kg/day/orally), royal jelly-cisplatin group, rats treated with royal jelly orally for 15 consecutive days by gavage (300 mg/kg/day) followed by a single injection i.p.
from CP (7 mg / kg body weight).
The obtained results revealed that the administration of royal jelly with cisplatin in rats significantly ameliorated the changes occurred in the biochemical parameters {GSH, GPx and CAT were significantly decreased in liver of cisplatin-treated rats and increasing ALT and AST}.
The histopathological results showed distinctive pattern of hepatotoxic changes in cisplatin group, while in the royal jelly-cisplatin group the liver tissues showed reductions lesions.
In conclusion, royal jelly acts in the liver as a potent scavenger of free radicals to prevent or ameliorates the toxic effects of CP as shown by biochemical and histopathological investigations and might provide substantial protection against cisplatin-induced hepatotoxicity and inflammatory damages.
American Psychological Association (APA)
Ashry, k.& al-Qadi, A. A.. 2014. Royal jelly modulates hepatotoxic effect of rats treated with cisplatin. Arab Journal of Nuclear Sciences and Applications،Vol. 47, no. 1, pp.172-180.
https://search.emarefa.net/detail/BIM-724177
Modern Language Association (MLA)
Ashry, k.& al-Qadi, A. A.. Royal jelly modulates hepatotoxic effect of rats treated with cisplatin. Arab Journal of Nuclear Sciences and Applications Vol. 47, no. 1 (Feb. 2014), pp.172-180.
https://search.emarefa.net/detail/BIM-724177
American Medical Association (AMA)
Ashry, k.& al-Qadi, A. A.. Royal jelly modulates hepatotoxic effect of rats treated with cisplatin. Arab Journal of Nuclear Sciences and Applications. 2014. Vol. 47, no. 1, pp.172-180.
https://search.emarefa.net/detail/BIM-724177
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 178-180
Record ID
BIM-724177