Radiation synthesis and characterization of N,O-carboxymethyl chitosan poly(vinylpyrrolidone)‎ copolymer hydrogel

Abstract EN

In this study, water soluble N,O-carboxymethyl chitosan (N,O-CMCs) was obtained by chemical treatment of chitosan with chloroacetic acid in alkaline condition.

The structure of N,O-carboxymethyl chitosan was confirmed by nuclear magnetic resonance (1H.NMR) and Fourier transform infrared spectroscopy (FT-IR) techniques.

The weight average molecular weight (MW) of the obtained (N,O-CMCs) was determined by a viscometric method.

The degree of substitution (DS%) was calculated from 1H.NMR spectra and by using potentiometric titration method.

The degree of substitution calculated from 1H.NMR spectrum was found to be close to that obtained using potentiometric titration method.

(N,O-carboxymethylchitosan/polyvinyl pyrrolidone) (N,O-CMCs/PVP) copolymer hydrogels were synthesized using gamma irradiation as clean source of initiation and crosslinking.

Preparation conditions such as effect of copolymer composition, concentration and irradiation dose on the gel content were investigated.

The prepared (N,O-CMCs/PVP) copolymer hydrogels were characterized using Fourier transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), X-ray diffraction (XRD) as well as studying the swelling behavior