The role of warfarin alone or in combination with certain natural products against blood disorders induced by gamma radiation in experimental animals

Abstract EN

The effect of warfarin against blood disorder induced by radiation and possible effect of certain natural products in modifying anticoagulant effect of warfarin in irradiated rats was investigated.

Prothrombin time (PT), international normalized ratio (INR), partial thromboplastin time (PTT), thrombin time (TT), fibrinogen level and platelet count were evaluated.

Furthermore, plasma level of malondialdehyde (MDA), reduced glutathione (GSH) and nitric oxide (NO) were determined.

The obtained data showed that irradiation elevated PT, INR, PTT, TT and fibrinogen level.

Moreover, irradiation increased MDA and NO levels while, reduced GSH level.

It was found that administration of garlic, fenugreek or green tea with warfarin for one week before irradiation resulted in elevation in PT and INR.

Results suggest that patients on warfarin and exposed to radiation are specifically advised to avoid taking herbal medicines or to have their PT and INR measured within two weeks of starting the drug, to be on a safer side.