Nigella sativa and panax ginseng supplementation ameliorate induced-hyperlipidemia in male rats

Abstract EN

The present work was conducted to study the effect of ginseng powder, ginseng oil, Nigella sativa seeds, Nigella sativa oil and combination of two oils on total cholesterol, triglycerides, adiponectin and some hormonal levels as testosterone.

T3, T4 and serum glucose level in rats fed either normal chew or high fat diet.

Nigella seed and oil, ginseng powder and oil and the combination of both oils decreased the highly level of cholesterol and triglycerides induced by fructose and high fat diet.

The potent one was nigella seed.

Nigella seed, Ginseng powder in addition to nigella and ginseng oils treatment ameliorate adiponectin suppression induced by high fat diet.

Rats fed normal diet supplied with nigella oil, ginseng oil and both oils show a highly significant decrease in adiponectin level.

Although nigella seed, nigella oil and the mixture of nigella and ginseng oils restored the hyperglycemia resulting from fructose administration to the normal level, but ginseng powder failed to affect this hyperglycemia.

High fat diet increased T3 and T4 levels, nigella oil and ginseng powder treatment reduced T3 level, however nigella seed restored T4 level.

Regarding the testosterone hormone, there was a significant increase in all hyperlipidemic group that received ginseng and nigella compared to positive control.Ginseng powder increased testosterone in rats fed normal diet.

In conclusion, administration of nigella and ginseng ameliorate the harmful changes in lipids and hormonal parameter induced by high fat diet.

As in lowering blood lipids, improving adiponectin level and regulating the body basal metabolic rates by controlling thyroid hormones level as well as increase the testosterone level in hyperlipidemic groups.