Assessment of serum vitamin D in type 1 diabetic patients from Gaza Strip

Other Title(s)

تقييم مستوى فيتامين د لدى مرضى السكر من النوع الأول في قطاع غزة

Dissertant

al-Hamlawi, Inas Muhammad Fathi Musa

Thesis advisor

Yasin, Majid Muhammad

Comitee Members

Abid, Abd Allah Assaf
al-Dalw, Ayyub Raghib

University

Islamic University

Faculty

Faculty of Science

Department

Department of Biological Science

University Country

Palestine (Gaza Strip)

Degree

Master

Degree Date

2015

English Abstract

Background: Type 1 diabetes usually strikes children and young adults.

Although vitamin D deficiency has been recently linked to diabetes, biochemical tests are restricted to traditional monitoring of glucose.

Therefore, introducing vitamin D test in Gaza hospitals and its supplementation may help in the management of the disease.

Objective: To assess serum vitamin D level in type 1 diabetic patients from Gaza Strip Materials and methods: This case-control study comprised 44 type 1 diabetic patients (22 males and 22 females) and 44 healthy controls (22 males and 22 females).

Questionnaire interview was applied.

Body mass index was determined.

Serum vitamin D, glucose, insulin, cholesterol, triglycerides, high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), Alkaline phosphatase, calcium and phosphorus were determined.

Blood glycated hemoglobin (HbA1c) was measured.

Data were computer analyzed using SPSS version 18.0.

Results: Type 1 diabetes mellitus was more frequent among individuals with family history of the disease (P<0.000).

Six (13.6%) of cases had no frequent monitoring of glucose level and more than one-third of cases were not on diet.

The mean duration of diabetes was found to be 9.1±7.0 years and the only self-reported complication among cases was retinopathy 2 (4.5%).

Insulin injection frequency/day showed that about two-thirds of the patients received two insulin doses/day.

The mean dose of insulin/day was 49.4±20.5 UI.cc/ml.

The mean level of vitamin D was significantly lower in cases compared to controls (34.1±19.1 versus 43.9±16.9 ng/dl, P=0.012).

The mean level of blood HbA1c and serum glucose and insulin levels were significantly higher in cases compared to controls (7.7±1.8%, 212.2±101.2 mg/dl and 23.4±16.4 l lU/ml versus 5.9±1.2, 75.0±14.4 and 13.0±12.9, P=0.000, P=0.000 and P=0.001, respectively).

The mean levels of cholesterol, triglycerides and LDL-C was significantly increased in cases than controls (197.0±45.6, 142.1±63.5 and 88.5±50.6 V mg/dl versus 152.9±30.7, 94.0±51.3 and 56.5±24.6, P=0.000, respectively).

Serum alkaline phosphatase (ALP) was also significantly increased in cases (164.2±129.6 versus 116.6±42.5 U/L, P=0.023).

Serum calcium was significantly lower in cases compared to controls (9.04±0.41 versus 9.38±0.56 mg/dl, P=0.024).

Vitamin D levels were found to be lower in individuals who were not doing physical activity (P=0.010).

Serum vitamin D levels showed significant negative correlations with HbA1c (r=- 0.258, P=0.015), insulin (r=-0.257, P=0.016) and LDL-C (r=-0.281, P=0.008), and significant positive correlation with calcium (r=0.251, P=0.018).

Conclusions: Serum vitamin D was significantly lower in type 1 diabetic patients compared to controls.

Serum vitamin D levels showed significant negative correlations with HbA1c, insulin and LDL-C, and significant positive correlations with calcium.

Main Subjects

Biology

No. of Pages

85

Table of Contents

• APA
• MLA
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Language

English

Data Type

Arab Theses

Record ID

BIM-724352