The role of yeast beta glucan on blood coagulation in streptozotocin-induced diabetes and irradiated rats

Abstract EN

Clotting abnormalities are observed after exposure to ionizing radiation as well as in diabetes melittus.

The objective of this study is to elucidate the role of yeast beta glucan (YBG) in the modulation of some biochemical variations observed in -irradiated, diabetic and diabetic-irradiated rats.

Gamma-irradiation was performed through the whole body exposure of rats to 6 Gy administered in four fractions of 1.5 Gy two times per week for two weeks.

Diabetes was induced by a single intraperitoneal injection of streptozotocin (55 mg/kg body weight).

YBG was given orally to male albino rats (1 g/kg body weight) for two weeks post irradiation and/or induction of diabetes.

Animals were divided into 4 main groups: 1- control, 2- -irradiated, 3- diabetic and 4- diabetic--irradiated rats.

Each group was subdiveded into 2 subgroups (a) untreated and (b) treated.

The 3rd and 14th day, after the last dose of radiation in the irradiated groups and after the induction of diabetes in diabetic groups, were chosen to evaluate the effect of oral YBG in irradiated and/or diabetic rats.