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Protective effect of quinine on chemical kindling and passive avoidance test in rats
Joint Authors
Yaghmaei, Parichehr
Faridkia, Zahra
Nassiri Asl, Marjan
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 18, Issue 9 (30 Sep. 2016), pp.1-5, 5 p.
Publisher
Publication Date
2016-09-30
Country of Publication
United Arab Emirates
No. of Pages
5
Main Subjects
Abstract EN
Background : In humans, convulsive diseases such as temporal lobe epilepsy are usually accompanied by learning and memory impairments.
In recent years, the role of gap junction channels as an important target of antiepileptic drugs has been studied and discussed.
Quinine, as a gap junction blocker of connexin 36, can abolish ictal epileptiform activity in brain slices.
Objectives : The role of quinine in memory retrieval in pentylenetetrazole (PTZ)-kindled rats was examined using a step-through passive avoidance task.
Methods : Forty rats were used in this experimental study in groups of 10 animals.
Quinine (15, 30, and 60 mg/kg, i.p.) and PTZ (35 mg/kg, i.p.) were injected into the rats before the start of the learning test.
Then, retention tests were conducted after the treatments ended.
Results : Quinine could attenuate seizure severity at doses of 15, 30 and 60 mg/kg compared with the control at the beginning of the kindling experiment by lowering the mean seizure stages (P < 0.01, P < 0.001, P < 0.001).
Quinine at doses of 15 and 30 mg/kg could significantly increase memory retrieval compared with the control in the retention test 24 and 48 hours after training (P < 0.05).
Quinine at a dose of 60 mg/kg increased latency to enter the dark chamber 24 and 48 hours after training (P < 0.001).
The results of the retention test one and two weeks after training of quinine were not significant (P > 0.05).
Conclusions : Quinine may decrease the severity of seizure and improve the memory retrieval of animals by inhibiting the gap junction channel.
However, further studies are needed to evaluate the molecular mechanism underlying the effects of quinine.
American Psychological Association (APA)
Faridkia, Zahra& Yaghmaei, Parichehr& Nassiri Asl, Marjan. 2016. Protective effect of quinine on chemical kindling and passive avoidance test in rats. Iranian Red Crescent Medical Journal،Vol. 18, no. 9, pp.1-5.
https://search.emarefa.net/detail/BIM-724916
Modern Language Association (MLA)
Faridkia, Zahra…[et al.]. Protective effect of quinine on chemical kindling and passive avoidance test in rats. Iranian Red Crescent Medical Journal Vol. 18, no. 9 (Sep. 2016), pp.1-5.
https://search.emarefa.net/detail/BIM-724916
American Medical Association (AMA)
Faridkia, Zahra& Yaghmaei, Parichehr& Nassiri Asl, Marjan. Protective effect of quinine on chemical kindling and passive avoidance test in rats. Iranian Red Crescent Medical Journal. 2016. Vol. 18, no. 9, pp.1-5.
https://search.emarefa.net/detail/BIM-724916
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 4-5
Record ID
BIM-724916