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The effect of aerobic exercise training on plasma apelin levels and pain threshold in T1DM rats
Joint Authors
Delavar, Rida
Heidarianpour, Ali
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 18, Issue 9 (30 Sep. 2016), pp.1-8, 8 p.
Publisher
Publication Date
2016-09-30
Country of Publication
United Arab Emirates
No. of Pages
8
Main Subjects
Abstract EN
Background : Diabetes mellitus (types 1 and 2) leads to secondary complications such as neuropathy, which reduce a patient’s quality of life.
Apelin and its receptor, APJ, have been shown to have antinociceptive effects and to decrease blood glucose levels.
Objectives : The present experimental study was conducted in Iran and investigated the role of apelin, which is used to manage type 1 diabetes mellitus, during exercise training.
Materials and Methods : Male Wistar rats (n = 36) were assigned by simple random allocation to six groups (n = 6): non-diabetic (ND), diabetic (D), sedentary non-diabetic (SND), sedentary diabetic (SD), exercise non-diabetic (END), and exercise diabetic (ED).
Diabetes was induced by a single subcutaneous injection of streptozotocin (50 mg / kg).
Exercise training consisted of treadmill running 60 minutes/day5 days/week for 10 weeks.
The tail-flick test was used to assess the thermal pain threshold, and an apelin enzyme immunoassay kit was utilized to assess plasma apelin levels.
Results: Plasma apelin level was higher (0.3 vs.
0.1, P < 0.0001) and the tail-flick latency was lower (2.2 vs.
3.8, P < 0.0001) in the D group than in the ND group.
After the training program, plasma apelin levels decreased in the exercise groups, and the tail-flick latency increased in the ED group.
No correlation was found between apelin blood concentrations and tail-flick latency following the training program in the ED group.
Conclusions : These findings suggest that apelin does not play any significant role in regulating the pain threshold in type 1 diabetes mellitus during exercise training.
American Psychological Association (APA)
Delavar, Rida& Heidarianpour, Ali. 2016. The effect of aerobic exercise training on plasma apelin levels and pain threshold in T1DM rats. Iranian Red Crescent Medical Journal،Vol. 18, no. 9, pp.1-8.
https://search.emarefa.net/detail/BIM-724966
Modern Language Association (MLA)
Delavar, Rida& Heidarianpour, Ali. The effect of aerobic exercise training on plasma apelin levels and pain threshold in T1DM rats. Iranian Red Crescent Medical Journal Vol. 18, no. 9 (Sep. 2016), pp.1-8.
https://search.emarefa.net/detail/BIM-724966
American Medical Association (AMA)
Delavar, Rida& Heidarianpour, Ali. The effect of aerobic exercise training on plasma apelin levels and pain threshold in T1DM rats. Iranian Red Crescent Medical Journal. 2016. Vol. 18, no. 9, pp.1-8.
https://search.emarefa.net/detail/BIM-724966
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 7-8
Record ID
BIM-724966