![](/images/graphics-bg.png)
Comparing zonisamide with sodium valproate in the management of migraine headaches : double-blind randomized clinical trial of efficacy and safety
Joint Authors
Assarzadegan, Farhad
Tabish, Hanif
Husayni Zijoud, Sayyid Mustafa
Beale, Andrew David
Shoghli, Arya
Yazdi, Mahmud Ghafuri
Mansuri, Behnam
Hesami, Omid
Muqaddim, Nahid Beladi
Kasmaei, Husayn Delavar
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 18, Issue 9 (30 Sep. 2016), pp.1-6, 6 p.
Publisher
Publication Date
2016-09-30
Country of Publication
United Arab Emirates
No. of Pages
6
Main Subjects
Abstract EN
Background : Migraine is one of the most debilitating medical conditions and has a high socioeconomic burden.
As conventional therapeutic methods do not entirely alleviate the symptoms, new alternatives are being considered.
Objectives : This study evaluates the efficacy and safety of zonisamide compared with sodium valproate in the management of migraine headaches.
Patients and Methods : In the current double-blind, parallel, randomized, controlled trial, 96 patients with a migraine diagnosis based on the international headache society (HIS) criteria were selected.
They were divided randomly into two groups; the case group was given zonisamide, and sodium valproate was given to a control group.
In addition to the side effects of the drugs, the severity, duration, and frequency of migraine attacks were evaluated at baseline and at three months.
Results : The 96 selected patients were divided randomly into two treatment groups (zonisamide n = 48, sodium valproate n = 48).
Seven patients were excluded from analysis because of early dropout, leaving 89 (n = 45; n = 44) patients for analysis.
While using zonisamide, six (13 %) patients complained of fatigue, and two (4 %) patients encountered noticeable appetite and weight loss.
In the control group, five (11 %) patients reported dizziness, and four (9 %) patients faced obvious appetite and weight gain.
Both drugs were considerably efficient in reducing further attacks.
There was no statistically significant correlation between frequency or severity of migraine attacks and the drug used for treatment in three months of follow-up.
Conclusions : Both medications are effective in reducing migraine attacks.
It will be important to consider the drugs’ adverse effects and availability and patients’ medical and socioeconomic condition to select the appropriate treatment.
American Psychological Association (APA)
Assarzadegan, Farhad& Tabish, Hanif& Husayni Zijoud, Sayyid Mustafa& Beale, Andrew David& Shoghli, Arya& Yazdi, Mahmud Ghafuri…[et al.]. 2016. Comparing zonisamide with sodium valproate in the management of migraine headaches : double-blind randomized clinical trial of efficacy and safety. Iranian Red Crescent Medical Journal،Vol. 18, no. 9, pp.1-6.
https://search.emarefa.net/detail/BIM-724979
Modern Language Association (MLA)
Assarzadegan, Farhad…[et al.]. Comparing zonisamide with sodium valproate in the management of migraine headaches : double-blind randomized clinical trial of efficacy and safety. Iranian Red Crescent Medical Journal Vol. 18, no. 9 (Sep. 2016), pp.1-6.
https://search.emarefa.net/detail/BIM-724979
American Medical Association (AMA)
Assarzadegan, Farhad& Tabish, Hanif& Husayni Zijoud, Sayyid Mustafa& Beale, Andrew David& Shoghli, Arya& Yazdi, Mahmud Ghafuri…[et al.]. Comparing zonisamide with sodium valproate in the management of migraine headaches : double-blind randomized clinical trial of efficacy and safety. Iranian Red Crescent Medical Journal. 2016. Vol. 18, no. 9, pp.1-6.
https://search.emarefa.net/detail/BIM-724979
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 6
Record ID
BIM-724979