Hepatitis associated aplastic anemia in relation to liver cell injury

Abstract EN

Background: Aplastic anemia (AA) is a disorder characterized by pancytopenia and injury or loss of pluripotent hematopoietic stem cells in the absence of infiltrative disease bf the bone marrow.

Hepatitis-associated aplastic anemia (HAAA) is a variant of AA.

Aim of the study: To investigate the possible etiology responsible for the development of HAAA.

Patients and methods: 42 patients were admitted to Assiut university hospital diagnosed as having AA.

Data frbm history, physical examination and laboratory investigations, including complete blood count (CBC), viral serology and liver function tests were collected and statistically analyzed.

Results: Patients were divided into group A (HAAA, 9 patients) 7 of them had hepatitis C virus, one with hepatitis ^ virus and one with cytomegalovirus and group B (non-HAAA, 33 patients).

There was no significant difference as regard to CBC between HAAA patients and non-HAAA patients.

There were significant negative correlations between alanine transaminase (ALT) and CBC findings in patients with HAAA.

Conclusion: HAAA is caused by variable hepatotropic and non-hepatotropic viruses.

The pathogenesis of hepatitis associated aplastic anemia HAAA may be attributed to liver cell injury, disturbed liver functions and its effects on hematopoiesis.