Fetuin-a and high sensitivity-crp in children with chronic kidney diseases
Other Title(s)
فيتوين-أ و بروتين ج المتفاعل عالي الحساسية في الأطفال المصابين بأمراض الكلى المزمنة
Joint Authors
Hashim, Ikram Ali
Sanusi, Khalid Abd al-Aziz
Taha, Samahir Fathi
Nasr, Iman H.
Hilal, Shaban Radwan
Muhammad, Ihab Mansur
Source
Issue
Vol. 39, Issue 2 (31 May. 2015), pp.99-112, 14 p.
Publisher
Assiut University Faculty of Medicine
Publication Date
2015-05-31
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Background: Fetuin-A is a circulating calcium- regulatory glycoprotein that inhibits vascular calcification.
In end stage renal disease (ESRD), fetuin -A has been demonstrated to be reduced and inversely related to cardiovascular mortality.
The present study aimed to determine the effect of renal function on serum levels of fetuin-A in patients with chronic kidney disease (CKD) and to investigate the relationship between fetuin-A serum level and vascular calcification which represents a risk factor for the development of endothelial dysfunction(ED).
Methods: 20 CKD patients on conservative treatment, 20 ESRD patients on regular hemodialysis (HD) treatment, as well as 40 apparently healthy controls of matchable age and sex were enrolled in the study.
All the patients and controls were subjected to the following investigations: estimation of serum levels of fetuin-A, high sensitivity-CRP( hs-CRP), creatinine, calcium (Ca), phosphorus (Po4), alkaline phosphatase (ALP), and parathormone (PTH).
In addition, glomerular filtration rate was estimated for cases and controls.
Results: There was significant reduction in fetuin-A serum levels in CKD and ESRD patients compared to controls.
A significant decrease was also detected in ESRD group when compared to CKD group.
The inflammation marker hs-CRP was significantly increased in CKD and ESRD patients in comparison to controls.
The increase was also significant on comparing ESRD group with CKD group.
A strong inverse correlation was found between serum fetuin-A and hs-CRP, Significantly increased serum levels of ALP and PTH were found in CKD and ESRD patients compared with controls.
The increase was also significant in ESRD patients compared with CKD patients.
In ESRD patients , Serum levels of fetuin-A showed significant inverse correlations with each of: duration of dialysis, ALP and PTH serum levels, while hs-CRP serum levels showed significant positive correlations with CaxPo4 ratio and PTH serum levels.
Conclusion: Results of the present study demonstrate that inflammatory processes are increased among CKD and ESRD patients and linked to low fetuin-A serum levels and vascular calcification which represents a risk factor for the development of ED.
The interaction of these incidents may be responsible for the development and progression of thrombogenesis in such casfes
American Psychological Association (APA)
Hashim, Ikram Ali& Hilal, Shaban Radwan& Sanusi, Khalid Abd al-Aziz& Muhammad, Ihab Mansur& Nasr, Iman H.& Taha, Samahir Fathi. 2015. Fetuin-a and high sensitivity-crp in children with chronic kidney diseases. Assiut Medical Journal،Vol. 39, no. 2, pp.99-112.
https://search.emarefa.net/detail/BIM-725961
Modern Language Association (MLA)
Hashim, Ikram Ali…[et al.]. Fetuin-a and high sensitivity-crp in children with chronic kidney diseases. Assiut Medical Journal Vol. 39, no. 2 (May. 2015), pp.99-112.
https://search.emarefa.net/detail/BIM-725961
American Medical Association (AMA)
Hashim, Ikram Ali& Hilal, Shaban Radwan& Sanusi, Khalid Abd al-Aziz& Muhammad, Ihab Mansur& Nasr, Iman H.& Taha, Samahir Fathi. Fetuin-a and high sensitivity-crp in children with chronic kidney diseases. Assiut Medical Journal. 2015. Vol. 39, no. 2, pp.99-112.
https://search.emarefa.net/detail/BIM-725961
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 108-111
Record ID
BIM-725961