Management of glioblastoma after recurrence : a changing paradigm
Joint Authors
Benson, Rony
Mallick, Supriya
Abd al-Hakim
Rath, Goura K.
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 28, Issue 4 (31 Dec. 2016), pp.199-210, 12 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2016-12-31
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Glioblastoma remains the most common primary brain tumor after the age of 40 years.
Maximal safe surgery followed by adjuvant chemoradiotherapy has remained the standard treatment for glioblastoma (GBM).
But recurrence is an inevitable event in the natural history of GBM with most patients experiencing it after 6–9 months of primary treatment.
Recurrent GBM poses great challenge to manage with no well-defined management protocols.
The challenge starts from differentiating radiation necrosis from true local progression.
A fine balance needs to be maintained on improving survival and assuring a better quality of life.
Treatment options are limited and ranges from re-excision, re-irradiation, systemic chemotherapy or a combination of these.
Re-excision and re-irradiation must be attempted in selected patients and has been shown to improve survival outcomes.
To facilitate the management of GBM recurrences, a treatment algorithm is proposed.
American Psychological Association (APA)
Mallick, Supriya& Benson, Rony& Abd al-Hakim& Rath, Goura K.. 2016. Management of glioblastoma after recurrence : a changing paradigm. Journal of the Egyptian National Cancer Institute،Vol. 28, no. 4, pp.199-210.
https://search.emarefa.net/detail/BIM-726050
Modern Language Association (MLA)
Mallick, Supriya…[et al.]. Management of glioblastoma after recurrence : a changing paradigm. Journal of the Egyptian National Cancer Institute Vol. 28, no. 4 (Dec. 2016), pp.199-210.
https://search.emarefa.net/detail/BIM-726050
American Medical Association (AMA)
Mallick, Supriya& Benson, Rony& Abd al-Hakim& Rath, Goura K.. Management of glioblastoma after recurrence : a changing paradigm. Journal of the Egyptian National Cancer Institute. 2016. Vol. 28, no. 4, pp.199-210.
https://search.emarefa.net/detail/BIM-726050
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p.207-210
Record ID
BIM-726050