Hemostatic profile of normal pregnant women in Gaza Strip

Other Title(s)

عوامل التجلط في النساء الحوامل طبيعيا في قطاع غزة

Dissertant

Muslim, Ilham Salim

Thesis advisor

Yasin, Majid M.

University

Islamic University

Faculty

Faculty of Science

Department

Department of Biological Science

University Country

Palestine (Gaza Strip)

Degree

Master

Degree Date

2016

English Abstract

Background: Normal pregnancy has been associated with alteration of the hemostatic system.

Pregnancy is recognized as a hypercoagulable state that protect women from potentially hemorrhage during placentation and the post-partum period.

Objective: To assess hemostatic profile of normal pregnant women in Gaza strip.

Materials and methods: This case-control design study included 105 healthy pregnant women subdivided into three groups each consists of 35 women comprising 1st, 2nd and 3rd trimesters, and 35 healthy non-pregnant women.

Questionnaire interviews were applied.

Hemostatic profiles were assessed.

Data were computer analyzed using SPSS program version 21.

Results: The mean ages of controls and pregnant women in the first, second and third trimesters were 29.0±5.1, 28.6±6.2, 28.7±5.8 and 28.9±6.1 years old, respectively.

Unemployment women and lower family income were more prevalent among pregnant women (P=0.004 and P=0.002, respectively).

Diastolic blood pressure recorded significant decrease in pregnant women compared to non-pregnant women (P=0.031).

PT and INR were significantly decreased as pregnancy progress (P=0.001).

Conversely, fibrinogen was significantly elevated in the 1st, 2nd and 3rd trimesters compared to controls (P=0.001).

RBCs count, Hb, platelets count, lymphocytes count and Ca concentration showed significant decrease in the three trimesters of pregnancy compared to controls (P=0.001, P=0.001, P=0.001, P=0.001 and P=0.003, respectively).

Whereas there were significant increases in the means of WBCs count, MID cells, granulocytes count and ESR in the three trimesters of pregnancy compared to controls (P=0.002 for WBC; P=0.030 for MID cells, P=0.001 for granulocyte and P=0.001 for ESR).

Similarly there was significant increase in MCV in the 3rd trimester compared to the 1s trimester (P=0.006).

MCHC displays significant increases in the 1st trimester with respect to controls and then significant decreases was recorded in the 2nd and 3rd trimesters compared to 1st trimester (P=0.001).

The Pearson correlation coefficient test showed significant positive correlations of fibrinogen with WBC (r=0.196, P=0.045), Granulocyte (r=0.219, P=0.025) and ESR (r=0.260, P=0.007) in pregnant women.

Conclusions: Hemostatic parameters were altered during pregnancy.

There were significantly increases in fibrinogen, WBC, MID, granulocytes, MCV and ESR during pregnancy.

In contrast PT, INR , lymphocytes, RBC, Hb, Hct, MCHC, platelets and calcium were significantly deceased.

Fibrinogen showed significant positive correlations with WBC, granulocyte and ESR.

Main Subjects

Biology

No. of Pages

61

Table of Contents

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Language

English

Data Type

Arab Theses

Record ID

BIM-727229