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Association of osteoprotegerin with obesity, insulin resistance and non-alcoholic fatty liver disease in children
Joint Authors
Erol, Meltem
Gayret, Ozlem Bostan
Yigit, Ozgul
Nacaroglu, Hikmat Tekin
Zengi, Oguzhan
Akkurt, Mehmet Salih
Tasdemir, Mehmet
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 18, Issue 11 (30 Nov. 2016), pp.1-9, 9 p.
Publisher
Publication Date
2016-11-30
Country of Publication
United Arab Emirates
No. of Pages
9
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Background : Osteoprotegerin (OPG) is a member of the tumor necrosis factor superfamily.
Reduced OPG levels are related to obesity, insulin resistance, and non-alcoholic fatty liver disease (NAFLD).
Objectives : The aim of this study was to evaluate the relationship between OPG levels, obesity, insulin resistance, and NAFLD in pediatric patients.
Methods : This was a prospective, cross-sectional, controlled study that was conducted in the department of pediatrics at Bagcilar training and research hospital in Istanbul, Turkey, between April and August 2015.
The study was performed on 107 children with obesity and 37 controls aged 5-17 years.
In the obese subset, 62 patients had NAFLD.
Homeostatic model assessment-insulin resistance (HOMA-IR) was used to calculate insulin resistance.
Insulin resistance was defined as a HOMA-IR value greater than 2.5.
Plasma OPG levels were measured using enzyme-linked immunosorbent assays.
NAFLD was diagnosed by hepatic ultrasound.
Results: The mean age was 11.25_3.38 years in the patient group and 10.41_3.15 years in the control group.
The OPG level in the obese group with the mean of 55.20_24.55 pg/mL (median = 48.81 pg/mL) was significantly lower than that in the control group with the mean of 70.78_ 33.41 pg/mL (median = 64.57 pg/mL) (P = 0.0001).
The optimal cut-off point (sensitivity, specificity) of the OPG level for the diagnosis of obesity was_46, 19 pg/mL.
According to logistic regression analysis, fasting insulin (P = 0.036) and OPG (P = 0.01) levels were most affected by obesity.
In the obese patients, who had HOMA-IR < 2.5, the mean level of OPG was 58.91 _ 6.88729 pg/mL (median = 49.55).
In the obese patients, who had HOMA-IR _ 2.5, the mean level of OPG was 54.19 _ 22.21 pg/mL (median = 48.47).
No significant correlations were found between OPG and HOMA-IR (P = 0.791).
No statistically significant difference was observed in the mean OPG between patients with hepatosteatosis (mean = 54.55_25.01 pg/mL) (median = 49.46) and those without the disease (56.30_24.02 pg/mL) (mean = 48.34) (P = 0.089).
Conclusions : We confirmed that serum OPG concentrations reduce in obese children.
However, no correlation was identified between OPG and insulin resistance.
OPG levels are not meaningful in the diagnosis of NAFLD in children with obesity.
American Psychological Association (APA)
Erol, Meltem& Gayret, Ozlem Bostan& Nacaroglu, Hikmat Tekin& Yigit, Ozgul& Zengi, Oguzhan& Akkurt, Mehmet Salih…[et al.]. 2016. Association of osteoprotegerin with obesity, insulin resistance and non-alcoholic fatty liver disease in children. Iranian Red Crescent Medical Journal،Vol. 18, no. 11, pp.1-9.
https://search.emarefa.net/detail/BIM-728767
Modern Language Association (MLA)
Erol, Meltem…[et al.]. Association of osteoprotegerin with obesity, insulin resistance and non-alcoholic fatty liver disease in children. Iranian Red Crescent Medical Journal Vol. 18, no. 11 (Nov. 2016), pp.1-9.
https://search.emarefa.net/detail/BIM-728767
American Medical Association (AMA)
Erol, Meltem& Gayret, Ozlem Bostan& Nacaroglu, Hikmat Tekin& Yigit, Ozgul& Zengi, Oguzhan& Akkurt, Mehmet Salih…[et al.]. Association of osteoprotegerin with obesity, insulin resistance and non-alcoholic fatty liver disease in children. Iranian Red Crescent Medical Journal. 2016. Vol. 18, no. 11, pp.1-9.
https://search.emarefa.net/detail/BIM-728767
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 8-9
Record ID
BIM-728767