Association between Methylene Tetrahydro Folate Reductase (MTHFR) gene polymorphisms and breast cancer in sample of Iraqi women
Other Title(s)
العلاقه بين تعدد الأشكال للجين مثيل تتراهايدرو فوليت المختزل (C677T) و سرطان الثدي في عينة من النساء العراقيات
Joint Authors
al-Bayyar, Izz al-Din Atiyyah
Ibrahim, Rim Khalid
Salman, Ihab Dawud
Source
Issue
Vol. 58, Issue 1C (31 Mar. 2017), pp.447-453, 7 p.
Publisher
University of Baghdad College of Science
Publication Date
2017-03-31
Country of Publication
Iraq
No. of Pages
7
Main Subjects
Abstract EN
Folate metabolism is fundamental and essential for DNA structure synthesis and repair.
Change in genes that participate in folate metabolism can be linked with different types of malignant tumor, Therefore, this study was conducted to find out the association between methylenetetrahydrofolatereductaseMTHFR gene polymorphisms and risk of breast cancer in a sample of Iraqi patients.
One Single Nucleotide Polymorphism ( SNP) including MTHFR C677T was calculated using a tetra primer ARMS PCR experiment assay.
The results explained that (MTHFR C677T) consists of three genotype (CC, CT, TT), The CC genotype was the most frequent in patients and control group ( 40.00%) and(60.00%) ,respectively, while the lowest frequency was for TT genotype(26.25%) in patients group .This study also revealed that the higher frequency 56.88 % for allele C and 43.12 % for T allele in patients group .
On the other hand the Odd Ratio ( O.R.) for CC, CT , TT genotypes were 1.073, 0.862 and 1.148 respectively, and the genotypes TT show a highest O.R.
American Psychological Association (APA)
Salman, Ihab Dawud& al-Bayyar, Izz al-Din Atiyyah& Ibrahim, Rim Khalid. 2017. Association between Methylene Tetrahydro Folate Reductase (MTHFR) gene polymorphisms and breast cancer in sample of Iraqi women. Iraqi Journal of Science،Vol. 58, no. 1C, pp.447-453.
https://search.emarefa.net/detail/BIM-729551
Modern Language Association (MLA)
Salman, Ihab Dawud…[et al.]. Association between Methylene Tetrahydro Folate Reductase (MTHFR) gene polymorphisms and breast cancer in sample of Iraqi women. Iraqi Journal of Science Vol. 58, no. 1C (2017), pp.447-453.
https://search.emarefa.net/detail/BIM-729551
American Medical Association (AMA)
Salman, Ihab Dawud& al-Bayyar, Izz al-Din Atiyyah& Ibrahim, Rim Khalid. Association between Methylene Tetrahydro Folate Reductase (MTHFR) gene polymorphisms and breast cancer in sample of Iraqi women. Iraqi Journal of Science. 2017. Vol. 58, no. 1C, pp.447-453.
https://search.emarefa.net/detail/BIM-729551
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 452-453
Record ID
BIM-729551