Potentiometric determination of Mebeverine hydrochloride using imprinted molecular polymer in PVC matrix membrane
Other Title(s)
التقدير المجاهدي لدواء المبرفين هيدروكلورايد باستعمال تقنية الطبعة الجزئية في قالب بولي فاينيل كلوريد
Joint Authors
al-Khafaji, Inas Hasan
al-Bayati, Yahya Kamal
Source
Issue
Vol. 57, Issue 4C (31 Dec. 2016), pp.2790-2799, 10 p.
Publisher
University of Baghdad College of Science
Publication Date
2016-12-31
Country of Publication
Iraq
No. of Pages
10
Main Subjects
Topics
Abstract EN
Four molecular imprinted polymer (MIP) membranes for Mebeverine.HCl (MBV.HCl) were prepared based on PVC matrix.
The imprinted polymers were prepared by polymerization of 2-acrylamido-2-methyl-1-propane sulphonic acid (AMPS) as monomer, pentaerythritoltriacrylate (PETRA) as a cross linker ,benzoyl peroxide (BPO) as an initiator and mebeverine as a template.
Four different types of plasticizers of different viscosities were used and the electrodes were fully characterized in terms of plasticizer type, response time, lifetime, pH and detection limit.
The MBV-MIP electrodes exhibited Nernstian response in concentration range from 1.0×10-6 to1.0×10-1 M with slopes of 13.98, 19.60, -20.43 and 19.01 mV/ decade.
The detection limit and quantification are found to be 4×10-6, 3× 10-6, 2× 10-5and 1.2× 10-6 M ,respectively.
Interference study for inorganic cations and amino acids was also studied.
The best electrode based tris (2-ethyl hexyl) phosphate plasticizer was applied successfully for potentiometric determination of mebeverine in commercial tablets.
Excellent average recovery obtained by potentiometric methods was about 102.26% which is in good agreements with British Pharmacopoeia.
American Psychological Association (APA)
al-Bayati, Yahya Kamal& al-Khafaji, Inas Hasan. 2016. Potentiometric determination of Mebeverine hydrochloride using imprinted molecular polymer in PVC matrix membrane. Iraqi Journal of Science،Vol. 57, no. 4C, pp.2790-2799.
https://search.emarefa.net/detail/BIM-733527
Modern Language Association (MLA)
al-Bayati, Yahya Kamal& al-Khafaji, Inas Hasan. Potentiometric determination of Mebeverine hydrochloride using imprinted molecular polymer in PVC matrix membrane. Iraqi Journal of Science Vol. 57, no. 4C (2016), pp.2790-2799.
https://search.emarefa.net/detail/BIM-733527
American Medical Association (AMA)
al-Bayati, Yahya Kamal& al-Khafaji, Inas Hasan. Potentiometric determination of Mebeverine hydrochloride using imprinted molecular polymer in PVC matrix membrane. Iraqi Journal of Science. 2016. Vol. 57, no. 4C, pp.2790-2799.
https://search.emarefa.net/detail/BIM-733527
Data Type
Journal Articles
Language
English
Notes
Text in English ; abstracts in English and Arabic.
Record ID
BIM-733527