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Prognostic significance of epithelial stromal caveolin-1 expression in prostatic hyperplasia, high grade prostatic intraepithelial hyperplasia and prostatic carcinoma and its correlation with microvessel density
Joint Authors
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 29, Issue 1 (31 Mar. 2017), pp.25-31, 7 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2017-03-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Caveolin-1 may play a role in cancer development and progression.
The aim was to record the expression and localization of caveolin-1 in benign prostatic hyperplasia (BPH), high grade prostatic intraepithelial neoplasia (HGPIN) and prostatic carcinoma (PCa).
Microvessel density was evaluated with CD34 immunostain.
Correlations with known prognostic factors of PCa were recorded.
Immunohistochemical expression of caveolin-1 and the MVD was evaluated in 65 cases; BPH (25), HGPIN (20) and PCa (20).
Stromal caveolin-1expression was significantly higher in BPH than HGPIN and PCca.
There was significant inverse relation between stromal caveolin-1 expression and extension to lymph node and seminal vesicle in carcinoma cases.
Epithelial caveolin-1 was significantly higher in carcinomas than in BPH and HGPIN.
Epithelial expression in carcinoma was significantly associated with preoperative PSA, Gleason score and lymph node extension.
MVD was significantly higher in PCa than in BPH and HGPIN.
There were significant relations between MVD and preoperative PSA, Gleason score, lymph node and seminal vesicle extension.
Stromal caveolin-1 was associated with low MVD while epithelial caveolin-1 with high MVD.
Conclusions: Caveolin-1 plays an important role in prostatic carcinogenesis and metastasis.
Stromal expression of caveolin-1 in PCa is lowered in relation to BPH and HGPIN.
In PCa; stromal caveolin-1 was associated with good prognostic parameters.
Epithelial caveolin-1 is significantly increased in PCa than BPH and HGPIN.
It is associated with clinically aggressive disease.
Caveolin-1 may play a role in angiogenesis.
American Psychological Association (APA)
Muhammad, Darin& Hilal, Duaa. 2017. Prognostic significance of epithelial stromal caveolin-1 expression in prostatic hyperplasia, high grade prostatic intraepithelial hyperplasia and prostatic carcinoma and its correlation with microvessel density. Journal of the Egyptian National Cancer Institute،Vol. 29, no. 1, pp.25-31.
https://search.emarefa.net/detail/BIM-733765
Modern Language Association (MLA)
Muhammad, Darin& Hilal, Duaa. Prognostic significance of epithelial stromal caveolin-1 expression in prostatic hyperplasia, high grade prostatic intraepithelial hyperplasia and prostatic carcinoma and its correlation with microvessel density. Journal of the Egyptian National Cancer Institute Vol. 29, no. 1 (Mar. 2017), pp.25-31.
https://search.emarefa.net/detail/BIM-733765
American Medical Association (AMA)
Muhammad, Darin& Hilal, Duaa. Prognostic significance of epithelial stromal caveolin-1 expression in prostatic hyperplasia, high grade prostatic intraepithelial hyperplasia and prostatic carcinoma and its correlation with microvessel density. Journal of the Egyptian National Cancer Institute. 2017. Vol. 29, no. 1, pp.25-31.
https://search.emarefa.net/detail/BIM-733765
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 31
Record ID
BIM-733765